Professor Mark von Itzstein, Director of Griffith University's Institute for Glycomics Credit: Griffith University Griffith University's Institute for Glycomics has made scientific history by determining the first three-dimensional image of a protein linked to the spread of cancer. The world-first imag...
Protein molecules are composed of light elements (mainly C,O,N and H) which give very little contrast and are so sensitive to radiation damage in the electron microscope that it is impossible to observe many details in a protein molecule before it has been......
of gene expression, protein localization and/or other analytic metadata with coordinate systems that place biomolecular localization and concentration into a spatial and biological context1,2,3. There are many other examples of dedicated databases for specific imaging projects, each tailored for specific...
Protein molecules are composed of light elements (mainly C,O,N and H) which give very little contrast and are so sensitive to radiation damage in the electron microscope that it is impossible to observe many details in a protein molecule before it has been destroyed by the electron beam. ...
Quick-freeze deep-etch replica electron microscopy combined with mica-flake technique provides high contrast, high time- and spatial-resolution images of protein molecules in solution, whose three-dimensional structure is well preserved. Thus, it might b
Paraformaldehyde is small molecule that penetrates cells/tissue quickly, fixing proteins and other molecules in place. Glutaraldehyde is a bigger molecule with two reactive aldehyde groups that increase the potential for fixation and help create long chains of glutaraldehyde, generating a matrix. This ...
Image-based phenotypic screening relies on the extraction of multivariate information from cells cultured under a large variety of conditions. Technical advances in high-throughput microscopy enable screening in increasingly complex and biologically rele
a physical arrangement that is particularly effective in trapping incoming light. The pigment molecule has two essential components—a protein called opsin and a covalently linked chromophore, the latter being a derivative of vitamin A. Absorption of energy from a photon of light causes the chromophor...
it is a powerful tool when used correctly to obtain unbiased quantitative data. In addition, quantitative data from IHC studies can be used to increase confidence in the specificity of the IHC protocol by correlating results from IHC with other measurements of the molecule of interest, such as ...
A microscopic image recognition system for detecting a protein-based molecule by presenting a recognition image is provided. The protein-based molecule has a state of a monomer. The microscopic image recognition system includes an image capturing unit, a monomer tracking module and a texture mask. ...