protein modelsselective agonistsstructure–activity relationshipsThe cover picture shows a model of the binding pocket of the estrogen receptor (ER) occupied by 8-VE2, a steroidal ER-selective agonist. As illustrated by the model, a single amino acid, methionine, accounts for the ER...
Overall, these comparisons show that the standard protein structure determination protocol with the program DIANA provides a picture of the protein structure ... KD Berndt,P Güntert,K Wüthrich - 《Proteins-structure Function & Bioinformatics》 被引量: 68发表: 2015年 Three-dimensional power Doppler...
25 The Geometric Structure of Possible Singularities for the Navier-Stokes and Eule 48:05 Wasserstein gradient flows for machine learning 1:02:17 Knot Floer homology of satellite knots 49:59 A survey on weak optimal transport 1:01:44 Conformal Walk Dimension_ Its Universal Value and the Non-...
The procedure introduces defined, site-specific structural changes that facilitate physicalorganic studies on this important class of macromolecules. In the background are examples of several of the over one hundred non-proteinogenic amino acids that have been successfully incorporated into proteins, ...
Water is present in the protein core up to a late stage of folding, lubricating conformational transitions during the search process. Once 80% of the native contacts have formed, water is squeezed from the protein interior and the structure descends into the native manifold. Examination of the ...
aNewly developed time-resolved and cryogenic trapping techniques [translate] aa wealth of data about the function of photoactive proteins [translate] acoherent picture of protein function remains a challenge. Here, [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙...
Unnatural amino acids can be incorporated as new building blocks into the genetic codes of both prokaryotic and eukaryotic organisms to facilitate studies of protein structure and function. Over 30 unnatural amino acids with modified side chains have been genetically encoded in response to unique triple...
Is an enzyme a protein or is a protein an enzyme? Explain. a. What is meant by allosteric regulation of enzymes? Include key/relevant terms (Enzyme, active site, effector, secondary site, conformational change, affinity and other terms you feel are rel...
Looking into an uncrystallized ballFor want of reliable and reproducible methods of crystallizing membrane proteins, it has been difficult to make predictions of their three-dimensional structures for drug research purposes. Taking a calculated approach, Fagerberg et al. applied seven protein structure ...
structure-activity relationshipsterpenoidsThe cover picture shows a schematic representation of the recognition principle of the ABC transporter complex TAP, which was deciphered by using combinatorial peptide libraries. By comparing individual sublibraries with the complex library, the effect of each amino...