Quick-freeze deep-etch replica electron microscopy combined with mica-flake technique provides high contrast, high time- and spatial-resolution images of protein molecules in solution, whose three-dimensional structure is well preserved. Thus, it might b
A microscopic image recognition system for detecting a protein-based molecule by presenting a recognition image is provided. The protein-based molecule has a state of a monomer. The microscopic image recognition system includes an image capturing unit, a monomer tracking module and a texture mask. ...
the spatial organizationof cellular structures and components. The assay is often used during drug screening to profile small molecules or other compounds on stained proteins in living cells. The pattern of cellular staining may revel morphological differences in samples treated by small molecule ...
It creates molecules through a painting-like approach that simultaneously depicts local structures and global layout of the molecule. By visualizing molecular structures, various design tasks are unified within a single image-based framework. De novo design becomes sketching new molecular images, whereas...
Paraformaldehyde is small molecule that penetrates cells/tissue quickly, fixing proteins and other molecules in place. Glutaraldehyde is a bigger molecule with two reactive aldehyde groups that increase the potential for fixation and help create long chains of glutaraldehyde, generating a matrix. This ...
Biologically produced protein drugs are generally susceptible to degradation by proteases and often exhibit immunogenicity. To address this issue, mirror-image peptide/protein binders consisting of D-amino acids have been developed so far through the mir
The STELLARIS family of confocal microscopes provides you with high-end solutions that enable the study of live cell specimens, detailed single molecule analysis or helps you maximize the results you get out of your experiments. Volumetric image of a Zebrafish beating heart Heart muscle cells (GFP...
Using mirror-image trypsin digestion and LC–MS/MS, we sequence a mirror-image large subunit ribosomal protein (L25) and a mirror-image Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4), and distinguish between different mutants of D-Dpo4. We also perform writing and reading of digital ...
Illustration of an oxycodone molecule (orange) about to bind to a mu-opioid receptor (blue) in a cell membrane (purple). Opioid receptors are found on nerve cells. When pain is detected by the body, endorphins are released and attach to the receptors, starting a reaction that modulates pain...
A Comprehensive Survey on Knowledge Distillation of Diffusion Models Weijian Luo [9th Apr., 2023] [arXiv, 2023] [Paper]A Survey on Graph Diffusion Models: Generative AI in Science for Molecule, Protein and Material Mengchun Zhang, Maryam Qamar, Taegoo Kang, Yuna Jung, Chenshuang Zhang...