David DeRosier –“Where in the cell is my protein.” 25:49 Bronwyn Lucas –“Towards single molecule Cryo -EM in cells.” 30:44 Elizabeth Villa –“Expanding the Toolkit for Structural Cell Biology.” 30:00 Julia Mahamid –“Enabling discovery by in cell structural biology.” 27:30...
The cover picture shows two features from the complex area of protein targeting in eukaryotic cells. The upper image illustrates the recruitment of the signal peptidase complex (SPC; light blue) and the oligosaccharidyl transferase complex (OST; green) to the ribosome–nascent polypeptide chain–...
- 《Journal of Archaeological Science》 被引量: 100发表: 2001年 Conformational sampling by NMR solution structures calculated with the program DIANA evaluated by comparison with long-time molecular dynamics calculations... Overall, these comparisons show that the standard protein structure determination ...
of optimal transport_ Lectu 1:18:42 Recent results in interface motions in the framework of optimal transport_ Lectu 1:23:44 Shift operators and their adjoints in several contexts 48:03 Subgraphs in Semi-random Graphs 51:53 Towards a Mathematical Theory of Developmental Biology_ Lecture 1 1:...
We've had a rather static view of enzymes over the years, despite the wealth of information that has come from both classical enzymology and structural biology. However, enzymatic catalysis and internal protein dynamics are closely linked, so how do we begin to study the dynamics of catalysis,...
Background / Purpose: Interaction databases must be integrated in order to obtain a more complete picture of the molecular biology of the cell. Main conclusion: We have integrated protein-protein, biochemical, gene regulatory, genetic and drug-target interactions from 30 databases into a global, se...
2008. Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments . Nature Structural & Molecular Biology 15 :... T Haslberger,A Zdanowicz,I Brand,... - 《Nature Structural & Molecular Biology》 被引量: 210发表: 2008年 Chimeric (α/β + α)-...
PAPPublish Ahead of Print PAPPhosphatidic Acid Phosphatase PAPPublic Advisory Council PAPPan-African Parliament(est. 2004) PAPPulmonary Artery Pressure PAPPhysical Activity Program(various locations) PAPProcessed Animal Protein(feed) PAPPharmaceutical Assistance Program(various locations) ...
Protein dynamics A motion pictureRachel Smallridge Nature Reviews Molecular Cell Biology volume 3, page 228 (2002)Cite this article 198 Accesses Metrics details In Science, Kern and colleagues now describe studies using NMR to characterize enzyme dynamics during substrate turnover in the human enzyme...
cancer antigens (neoantigens) are informing the development of personalized anticancer vaccines and cellular immunotherapies, but their efficacy may not just depend on tumour-associated mutations. Differences in the expression of a particular gene or in protein levels could also affect treatment response...