We generated E渭-myc mice that either lacked the IL-6 gene, or lacked the STAT3 gene specifically in B cells to determine the role of the IL-6/STAT3 pathway in tumor development. We found that IL-6 promotes the development of E渭-myc B cell lymphomas, but the B cell intrinsic ...
近日,中国医学科学院医药生物技术研究所蒋建东院士/彭宗根团队经过数年研究,揭示双环醇可通过抑制IL-6/STAT3信号通路改善晚期肝病。该项研究成果发表在Biomedicine & Pharmacotherapy杂志。 (研究发表封图) 该项研究利用二乙基亚硝胺(DEN)可诱导大鼠形成肝炎-肝纤维化-肝硬化-肝癌的特征,在不同阶段给予双环醇预防或治疗...
参考报价:￥1 - 4800 品牌:英拜生物 产地:上海 型号:IL6/STAT3信号转导通路PCR芯片IL6/STAT3 Signaling Pathway PCR Array 样本:来电或留言获取样本 在线咨询 留言咨询 电话咨询 收藏 AI问答 可以做哪些实验,检测什么? 可以用哪些耗材和试剂? 多少钱一台? 参数细节是什么? 使用的注意事项? 操作规程? 可以...
Icaritin inhibited the IL-6/Stat3 pathway, which is evidenced by the decreased expressions of p-Stat3 and Bmi-1. IL-6 treatment induced the phosphorylation of Stat3 and Bmi-1 expression, increased cell viability, as well as elevated glucose consumption, lactate production, and HK2 expression; ...
IL-6主要通过介导信号转换和转录激活因子3( STAT3>信号传导通路( IL-6/STAT3信号传导通路) 来调节肿瘤细胞的增殖和分化。因此,IL-6/STAT3信号传导通路的阻断,对肿瘤具有潜在治疗意义。【关键词】 肿瘤;白细胞介素6;STAT3转录因子;信号传导Targeti ng theIL- 6/STAT3si gnal i ng pathwayi n cancer treatment...
第一部分:IL-6-STAT3信号通路调控胃癌铁调素水平 方法: 1.应用双抗体夹心酶联免疫吸附法(Enzyme-LinkedImmunoSorbentAssay,ELISA) 检测血清中Hepcidin和IL-6水平,并统计分析Hepcidin与IL-6水平的相关性。 2.应用实时荧光定量PCR(RealTimeFluorescentQuantitativePCR,RTFQ-PCR)法 ...
因此,纽约州立大学石溪分校医学院教授林军团队使用小鼠模型来研究不同麻醉药物对于癌症转移的作用,并且进一步揭示其机理。该成果于发表在Nature Communications,题为:Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models(第一作者:李茹博士,黄毓杰博士)。
GC-MSCs activated STAT3一ERKl/2 signaling pathway in neutrophils,contributing to the induction of IL8 and the pro-metastatic and pro-angiogenic functions.GC-MSCs secreted high level of IL6 and blocking the IL6/IL6R interaction inhibited the activation of neutrophils by GC-MSCs.In turn,GC-MSCs...
结论 :HK -2 细胞中, JAK2/STAT3 信号通路的激活可能参与了 IL-6 介导的肾小管上皮细胞转分化的发生。〔关键词〕 白细胞介素-6 上皮细胞转分化 Janus激酶和信号转导因子和转录活化因子Role of Jak2/Stat3 Pathway in IL-6-Induced Epithelial -Myofibroblast TransdifferentiationZHAN Linda , ZHOU Zaisheng , ...
Abstract 2861: A novel negative regulation principle between DAPK and STAT3 in inflammation-associated carcinogenesis. It has been shown that the TNF-IL-6-STAT3 pathway plays a crucial role in promoting ulcerative colitis associated carcinoma (UCC). As inflammation compromises gut homeostasis and is ...