IL-4 和 IL-13 在交替激活的巨噬细胞中诱导 c-Myc 表达(MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression. Journal of Leukocyte Biology.),相反,LPS 诱导的 HIF-1α 上调与 c-Myc 下调同时发生Myc 。总体而言,在没有二次刺激的情况下,训练...
第二，信号依赖的转录因子，包括IL-4和IL-13活化的STAT6，IFN-r活化的STAT1以及LPS活化的NF-kB或AP-1，决定了巨噬细胞极化和炎性信号的即早（immediate-early）转录响应【8】。第三，巨噬细胞极化信号所诱导或活化的转录因子，比如IL-4诱导的EGR2或IFN-r活化的IRF1和IRF8均参与决定巨噬细胞极化以及下游转录因...
Intriguingly, in our previous work we showed that inflammatory breast cancer (IBC) cells are hyper-migratory in response to macrophage conditioned media. Additionally, we found this process is regulated by the Rho-GTPase, RhoC. Recent advances in tumor associated macrophage (TAM) biology have led ...
作者发现,衰老过程中,人血细胞中 IL4R、IL13RA1 和 STAT6 的表达逐渐减少(图 1A、1B)。同样,与年轻小鼠(3 个月大)相比,老龄小鼠(22 个月大)多个组织中的 Il4ra、Il4、Il13 和 Stat6 的表达量也有所下降(图 1C)。与这种表型同时出现的是 DNA 损伤和衰老标志物 p53 的较高表达量(图 1D)。这些...
XY-E30437 【中文名称】大鼠巨噬细胞炎症蛋白5(MIP-5)ELISA试剂盒品牌 【英文名称】Rat macrophage inflammatory protein 5,MIP-5 ELISA试剂盒多少钱 XY-E30438 【中文名称】大鼠可溶性细胞间粘附分子1(sICAM-1)ELISA试剂盒品牌 【英文名称】Rat Soluble Intercellular Adhesion Molecule 1,sICAM-1 ELISA试剂盒多少钱...
(IL-4Ra)-dependent macrophage activation con- trolled collagen fibril assembly and that this process was important for effective repair while having adverse pro-fibrotic effects. We identified Relm-a as one important player in the ...
macrophageanddendriticcells.TheycanactivateBcelltoproduceIefi,stimulatetheairwayepithelialcellandgobletcelltoproducegrume,andactivateairwaysmoothmusclecellstocausebronchialhyperresponsiveness.Furthermore,theyplayavitalroleinallergicinflammationonthebasisofthesignalpathwayofIL一4/IL一1 3,Signalingbyblocking11—4/IL-13...
IL-4 induces macrophage activation and TSLP production. IL-4 recruits and activates IgE-producing B cells (IgE class switching) and enhances IgE-mediated responses by up-regulating IgE receptors on B lymphocytes, mast cells, and basophils. In addition, IL-4 also induces VCAM-1 on vascular ...
13途径抑制剂。在某些实施方案中,所述il ‑ 4/il ‑ 13途径抑制剂增强pd ‑ 1阻断的抗肿瘤效力。 背景技术: 2.2型免疫在多种癌症类型中促进肿瘤生长和转移。数种2型相关细胞因子、趋化因子或受体与癌症有关,并在多种人肿瘤中过表达。例如,il ...
Here we used single-cell RNA sequencing of human and mouse non-small cell lung cancer (NSCLC) lesions, and found that in both species the type 2 cytokine interleukin-4 (IL-4) was predicted to be the primary driver of the tumour-infiltrating monocyte-derived macrophage phenotype. Using a ...