研究制备IL-10自分泌CAR-T细胞(IL-10-HER2-CAR-T),通过自分泌IL10使CAR-T细胞在肿瘤微环境中维持线粒体结构和功能完整性,并以线粒体丙酮酸转运体(mitochondrial pyruvate carrier, MPC)依赖的方式增强氧化磷酸化代谢促进细胞增殖和效应功能。实验结合黑色素瘤模型、乳腺癌肺转移肿瘤模型、结肠癌皮下肿瘤模型以及人...
CART迄今为止在实体瘤中的疗效有限,主要因为复杂的肿瘤微环境(TME)导致CAR-T细胞迅速耗竭并失去杀伤肿瘤的功能。
一种融合表达Ⅰ型IL-10受体的第四代CAR-T细胞及其制备方法与应用本发明公开了一种融合表达Ⅰ型IL10受体的第四代CART细胞及其制备方法与应用.通过慢病毒感染方法将表达第四代CAR结构(scFvIL10RCD2841BBCD3ζ)慢病毒感染CD3章晓联刘传刚
Liver disease is a leading contributor to morbidity and mortality during HIV infection, despite the use of combination antiretroviral therapy (cART). The precise mechanisms of liver disease during HIV infection are poorly understood partially due to the difficulty in obtaining human liver samples as we...
Bulk request >> Add to cart For research use only. Order now, ship in 3 days Product Details Related Products Antibody Details Format Details Alternate Names CSIF, Cytokine synthesis inhibitory factor, IL-10, Interleukin-10 Clone No JES5-16E3 Leadtime Order now, ship in 3 days Backgro...
众所周知,人体内有一类叫做淋巴细胞的白细胞,执行着人体的免疫功能,是对抗外界感染和监控体内细胞变异的一线“士兵”。而在淋巴细胞中,有一类叫做TIL(肿瘤浸润淋巴细胞)的特殊群体,它们是指那些离开血流进入到肿瘤中的白细胞。当存在大量的肿瘤浸润淋巴细胞时,表明机体启动了对抗肿瘤的免疫反应。
IL10 recombinant monoclonal antibody, clone IL10/2651R, RAB00460, highly specific and rigorously validated in-house for Immunohistochemistry (IHC). Reacts with Human.IL10 recombinant monoclonal antibody, clone IL10/2651R, RAB00460 is ready to ship.
IL10RA DNAxPab, H00003587-W01P, high quality and rigorously validated in-house for Western Blot (WB), Immunocytochemistry (ICC/IF), Flow Cytometry (Flow). Rabbit polyclonal antibody raised against a partial-length human IL10RA DNA using DNAx™ Immun
本发明涉及通过施用IL10药剂来调节CART细胞的活性以治疗疾病,病症和病况的方法.本发明进一步提供了工程改造的CART细胞以表达额外的治疗有效的药剂.本发明进一步提供了与CART细胞疗法在哺乳动物受试者中的疾病治疗中的用途相关的改进的药物和治疗组合物以及... S·A·麦考利,M·奥夫特 被引量: 0发表: 2021年 ...
Murine IL-10 ELISA Kit, 2 x 96-well (pre-coated) Be the first to review this product Datasheet SDS $585.00 3 Weeks* Size Qty Add to Cart Specifications Specifications Product Data Species Mouse Format 2 x 96-well (pre-coated) Assay Type Solid Phase Sandwich ELISA As...