[4]Salazar J, Martínez MS, Chávez-Castillo M, et al.C-Reactive Protein: An In-Depth Look into Structure, Function, and Regulation[J]. Int Sch Res Notices. 2014 Dec 15;2014:653045. [5]Rhodes B, Fürnrohr BG, Vyse TJ.C-reactive p...
近日,来自耶鲁大学药学院的Andrew Wang 研究团队在Cell上发表了题为Origin and Function of Stress-Induced IL-6 in Murine Models的研究,揭示了应激状态产生的IL-6的主要来源是棕色脂肪组织,并阐明了IL-6水平升高的重要的生理学意义。 作者发现,与之前报道一致,小鼠在不同的压力刺激下 (如更换笼子,社交隔离等) ...
参考文献 [1] Simpson RJ, Hammacher A, Smith DK, et al. Interleukin-6: structure-function relationships[J]. Protein Sci,1997, 6(5): 929-55. [2]Uciechowski P, Dempke WCM. Interleukin-6: A Masterplayer in the Cytokine Network[J]. Oncology, 2020, 98(3): 131-137. [3]Mihara M, ...
Eur J Heart Fail. 2023;25(2):174-184. doi:10.1002/ejhf.2767 5.Qing H, Desrouleaux R, Israni-Winger K, et al. Origin and Function of Stress-Induced IL-6 in Murine Models [published correction appears in Cell. 2020 Sep 17;182(6):1660].?Cell. 2020;182(2):372-387.e14. doi:10....
近日,来自耶鲁大学药学院的Andrew Wang 研究团队在Cell上发表了题为Origin and Function of Stress-Induced IL-6 in Murine Models的研究,揭示了应激状态产生的IL-6的主要来源是棕色脂肪组织,并阐明了IL-6水平升高的重要的生理学意义。 作者发现,与之前报道一致,小鼠在不同的压力刺激下 (如更换笼子,社交隔离等) ...
27 And, as previously noted, IL-6 gene expression in murine soleus muscle has been shown to decrease in the microgravity of spaceflight,81 and spaceflight impairment in osteoblast function has been attributed to a reduction IL-6 mRNA expression.71 As documented in this review, reductions in the...
Despite significantly blocking IL-6 function and expression respectively (Fig. S4a), neither antibody nor siRNA treatment affected CFs or STFs contraction (Fig. 4c). Likewise, IL-6 did not substantially stimulate contraction (Fig. 4d). Scientific Reports | 6:28261 | DOI: 10.1038/srep28261...
[23] Ross SH, et al. Signaling and function of interleukin-2 in T lymphocytes. Annual review of immunology. 2018 Apr 26;36(1):411-33. [24] Mitra S, et al. Biology of IL-2 and its therapeutic modulation: mechanisms and strategies. Journal of leukocyte biology. 2018 Apr;103(4):643...
近日,耶鲁大学医学院免疫学系Andrew Wang团队在Cell杂志上发表了题为:Origin and Function of Stress-Induced IL-6 in Murine Models的研究论文。 该研究破解了困扰科学界30年的问题,回答了急性应激引起的IL-6水平的升高对机体功能影响...
最近一项研究表明,负面情绪引发的焦虑情绪会直接导致肥胖。该研究于2020年7月,由耶鲁大学药学院 Andrew Wang 团队在国际顶尖学术期刊 Cell 杂志发表,题为:Origin and Function of Stress-Induced IL-6 in Murine Models 。 该研究对焦虑如何引发人体肥胖的机制有了新的发现,即外界压力会使细胞因子白细胞介素-6(IL...