This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor ...
Identification and character- ization of a novel IL-4 receptor antagonist for allergy treatment. Intern. Med. J. 42, 1.Ahmed N, Dhanapala P, Suphioglu C. Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling. Cell Physiol ...
A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness The closely related Th2 cytokines, IL-4 and IL-13, share many biological functions that are considered important in the deve4-opment of aller...
The human IL-1 receptor antagonist gene(ILIRN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta Ioci. Genomics,1992;13(3):654-7 [4]DinareIIo CA. Is there a role for inter Ieukon-1 blockade in intravenous immunogobu Iin therapy? ImmunoI.Rev,1994;139...
nuanced approaches to vaccination design is of great importance. Studies in our laboratory have shown that a pox viral vector-based prime-boost vaccine strategy that co-expresses HIV antigens together with an IL-4 receptor antagonist can drastically improve avidity, poly-functionality and cytotoxicity...
Soluble IL-4 receptor (IL-4R) may act as a natural antagonist. Here we show that human sIL-4R inhibits those functions of human Th2 cells which result from elevated IL-4 production, e.g. allergen-induced proliferation and help for allergen induced IgE synthesis. The inhibitory effect of ...
Knowledge of the details of the recognition mechanism will finally allow highly specific growth factors to be designed that are able to distinguish between different receptor combinations, as shown for the T-cell specific IL-4 antagonist IL-4R121E [63, 64] or the IL-13 cytotoxin fusion used ...
(参见例如Blaeser等人(2003)Targeted inactivation of the IL-4 receptor a chain I4R motif promotes allergic airway inflammation,J Exp Med 198(8):1189-1200)。 [0203]为了证实配体特异性和受体功能性,使用来源于人源化IL-4Rα小鼠的原代细胞。使用在DMEM中的来自野生型和人源化IL-4Rα小鼠的股骨骨髓...
recognition mechanism will finally allow highly specific growth factors to be designed that are able to distinguish between different receptor combinations, as shown for the T-cell specific IL-4 antagonist IL-4R121E [63,64] or the IL-13 cytotoxin fusion used for treatment of several cancers [...
IFN-γ, a known antagonist of the IL-4-induced CD23 expression, acted synergistically with the steroid, and resulted in a nearly complete suppression (90–95%) upon cotreatment (Fig. 1A). Such inhibitory effects of the corticosteroid were also observed with U937 and Ramos, established ...