AntagonistIL-13IL-4ProteinstructureInterleukin-4 (IL-4) and IL-13 are the only cytokines known to bind to the receptor chain IL-4Rα. Receptor sharing by these two cytokines is the molecular basis for their overlapping biological functions. Both are key factors in the development of allergic...
猪白介素1受体拮抗剂(IL1Ra)ELISA试剂盒 Porcine Interleukin 1 receptor antagonist, IL-1ra ELISA试剂盒 猪高铁血红蛋白(MHB)ELISA试剂盒 Porcine Methemoglobin,MHB ELISA试剂盒 猪Ⅲ型前胶原氨基端肽(PⅢNT)ELISA试剂盒 Porcine procollagen Ⅲ N-terminal peptide,PⅢNT ELISA试剂盒 公司简介 上海烜雅生物...
Identification and character- ization of a novel IL-4 receptor antagonist for allergy treatment. Intern. Med. J. 42, 1.Ahmed N, Dhanapala P, Suphioglu C. Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling. Cell Physiol ...
A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness The closely related Th2 cytokines, IL-4 and IL-13, share many biological functions that are considered important in the deve4-opment of aller...
IL- I ra appears to be a pure receptor antagonist, binding to IL-I receptors but not activating target cells. Human IL- I ra binds to the type I IL-I receptor on murine EL4-6.1 cells with an affinity of 150 pM, equal to the binding of human IL-la and IL- 1b(25). Furthermore...
Racioppi L, Ronchese F, Matis LA, Germain RN: Peptide-major histocompatibility complex class II complexes with agonist/antagonist properties provide evidence for ligand related differences in T cell receptor dependent intracellular signaling. J Exp Med. 1993, 177: 1047-1060. 10.1084/jem.177.4.1047 ...
IL-1虽未广泛用于人体研究,但其对免疫系统的特殊作用使它在临床应用方面具有诱人的前景。另外,由于IL-1也参与机体的多种病理过程,所以研究IL-1抑制物可能也具有实际意义。现已克隆出IL-1受体拮抗剂(IL-1 receptor antagonist,IL-1RA),该物质可在体内外封闭IL-1的活性,是一种较理想的IL-1封闭因子。
nuanced approaches to vaccination design is of great importance. Studies in our laboratory have shown that a pox viral vector-based prime-boost vaccine strategy that co-expresses HIV antigens together with an IL-4 receptor antagonist can drastically improve avidity, poly-functionality and cytotoxicity...
The interleukin-4-receptor: from recognition mechanism to pharmacological target structure. Angew. Chem. Int. Ed. Engl. 39, 2834–2846 (2000). CAS PubMed Google Scholar Lewis, D. B. Allergy immunotherapy and inhibition of TH2 immune responses: a sufficient strategy? Curr. Opin. Immunol. ...
(参见例如Blaeser等人(2003)Targeted inactivation of the IL-4 receptor a chain I4R motif promotes allergic airway inflammation,J Exp Med 198(8):1189-1200)。 [0203]为了证实配体特异性和受体功能性,使用来源于人源化IL-4Rα小鼠的原代细胞。使用在DMEM中的来自野生型和人源化IL-4Rα小鼠的股骨骨髓...