参考文献: 1.Cho JM, Koh JH, Kim SG, et al. Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function. Commun Biol. 2023 Jul 14;6(1):722. 2.Lebal-ILARIS®(canakinumab). FDA. Link...
Interleukin-1 receptor antagonist (IL-1Ra) is unique among primary inflammatory cytokines because its molecular activity is entirely passive and negative (1鈥 3) . Because it is a pure antagonist of the inflammatory cytokine IL-1, a deficiency of IL-1Ra not only reveals processes for which IL...
主要包括参与介导炎症反应、调节免疫、调节机体代谢.IL-1分子重量为17.5KD,有两种类型:IL-1a和IL-1B,主要以IL-1B为主.IL-1受体(interleukin-1 receptor,IL-1R)包括Ⅰ型和Ⅱ型,此外还存在一种内源性IL-1受体拮抗剂 (interleukin-1 receptor antagonist,IL-1ra或IL-1Y),IL-1ra可以与IL-1受体结合,但是不...
Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Inter...
Interleukin-1 receptor antagonist (IL-1ra) is an inhibitor of the proinflammatory IL-1. The IL-1ra gene ( Il1rn ) maps near the allergen-induced bronchial hyper-responsiveness-1 locus, Abhr1 , which we previously mapped to murine chromosome 2 using A/J (asthma susceptible) and C3H/HeJ ...
The present invention provides novel therapeutic uses for interleukin-1 receptor antagonists for conditions related to interleukin-18, interleukin-12 and interferon-. The present invention also provides novel methods for modulating B cell proliferation.John FordAlice Ho...
IL-1 受体拮抗剂多态性与硬膜外镇痛产妇产时发热的孟德尔随机化研究 《British Journal of Anaesthesia》:Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study...
Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL...
上海沪震实业有限公司生产的Eukaryotic Interleukin 1 Receptor Antagonist (IL1RA),最新报价:1950元/ug,EukaryoticInterleukin1ReceptorAntagonist(IL1RA)SequenceInformationSpecies:HumanG
A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development. FASEB J 2004; 18: 161-163.Bar D,Apte RN,Voronov E. A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development[J].{H}FASEB JOURNAL 2004...