Specific attention is paid to the comparison with the original compound from which the peptides were originated: the IL-1 receptor antagonist (IL-1RA) protein. The potential advantages brought about by the present invention as well as the limits documented by the experimental results shown in the...
Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Inter...
Several IL-1 blocking drugs are already available. These include IL-1 receptor antagonist (IL-1Ra) anakinra, human monoclonal antibody against IL-1β canakinumab and gevokizumab, and a soluble IL-1 receptor chimeric fusion protein that neutralizes both IL-1α and IL-1β rilonacept [87]. IL...
Drugs, InvestigationalGene TherapyDrug Evaluation, PreclinicalModels, AnimalInterleukin 1 Receptor Antagonist ProteinInterleukin-1IL-1 is a pleiotropic cytokine shown to play a major role in synovitis and in the mechanisms that lead to the progressive joint destruction of rheumatoid arthritis (RA). IL-...
Interleukin (IL)-1α and IL-1β are proinflammatory cytokines that play a role in many diseases such as rheumatoid arthritis, juvenile rheumatoid arthritis, gout, and periodic inflammatory syndromes, including familial Mediterranean fever and Muckle-Wells syndrome. Drugs targeting IL-1 such as recombi...
Over the last years, novel biological drugs have been developed to antagonize the pathophysiological actions of IL-1β. The drugs currently used in clinical practice are anakinra, a recombinant form of the naturally occurring IL-1 receptor antagonist, the soluble decoy receptor rilonacept and the ...
This might be related to the reduced activation of the IL-1β pathway as suggested by the reduction of (activated) caspase-1 activity in our experiments, as already reported with the human recombinant IL-1β receptor antagonist anakinra (23). However, it cannot be excluded that the caspase-...
Modulation of IL-1β and MMP9 gene expression, molecular content, activity and release was investigated in relation to PL instability. Here we demonstrated for the first time in ex-vivo human vessel tissue cultures the post-transcriptional efficacy of P2X7-specific antagonist, A740003, in ...
F. (1995) Interleukin-1 receptor antagonist attenuates the heat stroke-induced neuronal damage by reducing the cerebral ischemia in rats. Brain Res. Bull. 37, 595–598. CrossRef Meldrum, B. S. and Chapman, A. G. (1994) Competitive NMDA antagonists as drugs, in The NMDA Receptor (...
Significantly, IL-1 blockade with IL-1R antagonist reduced tumor growth and metastasis in preclinical breast cancer models. Our results show that inflammasome and IL-1β enhance tumor growth and metastasis in breast cancer models. Currently, the role of inflammasomes in tumor initiation, growth and...