1.Cho JM, Koh JH, Kim SG, et al. Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function. Commun Biol. 2023 Jul 14;6(1):722. 2.Lebal-ILARIS®(canakinumab). FDA. Link:https://...
Management and Monitoring of the Interleukin-1 Mediated Autoinflammatory Diseases: Cryopyrin-Associated Periodic Syndromes, Tumour Necrosis Factor Receptor-Associated Periodic Syndrome, Mevalonate Kinase Deficiency, and Deficiency of the Inter...
Specific attention is paid to the comparison with the original compound from which the peptides were originated: the IL-1 receptor antagonist (IL-1RA) protein. The potential advantages brought about by the present invention as well as the limits documented by the experimental results shown in the...
IL-1β 基因表达和前 IL-1β 合成在模式识别受体 (PRR) 激活后发生。炎症刺激还会驱动含有 CARD 和 PYHIN 结构域的 PRR 的激活,这些 PRR 会募集 ASC 和 caspase-1 (Casp-1) 组装成多蛋白复合物炎症小体。Pro-Casp-1(由 pro-Casp-1 编码)由炎症小体激活,将 pro-IL-1β 裂解为具有生物活性的 IL-...
In the present study, we determine the relative contribution of different inflammasomes to infection and inflammation in CF mice, assessed the therapeutic efficacy of the recombinant IL-1R antagonist (IL-1Ra), anakinra, and evaluated whether genetic variations in the inflammasome/IL-1RI signalling cou...
英文名称: Recombinant Porcine Interleukin-1 Receptor Antagonist 纯度: 97 % 别名: 重组猪白介素1拮圄剂|Porcine IL-1RA 产地: 以色列 品牌: PROSPEC 包装规格: 20ug ProSpec (蛋白质专家)是以色列一家具有超过 16 年历史的,专业从事细菌来源重组蛋白生产的先进生物技术公司。 ProSpec 生产多种细胞因...
antagonist (IL-1ra), matrix metallopeptidase-9 (MMP-9), and interleukin-6 (IL-6), were compared between VFD and normal PRP samples, including both leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP). VFD was prepared using two rounds of centrifugation. LP-PRP and LR-PRP were...
FDA food and drugs administration FMF Familial Mediterranean Fever HNSCC head and neck squamous cell carcinoma hs-CRP high-sensitivity C-reactive protein ICANS immune effector cell-associated neurotoxicity syndrome IFN-γ interferon-γ IL-1 interleukin 1 IL-1R IL-1 receptor IL-1Ra IL-1R antagonist ...
The IL-1 family also contains four members that suppress inflammation: two specific receptor antagonists (IL-1 receptor antagonist (IL-1Ra) and IL-36 receptor antagonist (IL-36Ra)), and two members that broadly suppress innate inflammation by non-specifically reducing several cytokines and ...
The interleukin 1 receptor system within the spinal cord has been implicated in the amplification of pain signals, and its central antagonism provides relief of neuropathic pain. Targeting the IL-1 system in the spinal cord with biologic drugs, however, raises the even greater challenge...