Human IL-2 mutein with higher antitumor efficacy than wild type IL-2. J Immunol. 2013 Jun 15;190(12):6230-8. doi: 10.4049/jimmunol.1201895. Epub 2013 May 15. PMID: 23677467. [8].Waldmann TA. The role of the multichain IL-2 receptor complex in the control of normal and malignant ...
Finally, we explored other mutations, orientation, and linkers to generate a potent, selective molecule with drug-like manufacturability. These structure activity relationship efforts culminated in the generation of PT101, a mutant IL-2 Fc fusion that was selective in activating and expanding Tregs. ...
“We are very excited to have reached a collaborative agreement with Almirall for the development of SIM0278. This innovative IL-2 mutein is one important molecule of our immune-rebalancing strategy for autoimmune diseases”, saidRenhong Tang, Ph.D., Co-CEO of Simcere, “SIM0278 i...
B. et al. A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease. J. Autoimmun. (2018). Khoryati, L. et al. An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice. Sci. ...
Preclinical studies of the T cell growth factor activity of IL-2 resulted in this cytokine becoming the first immunotherapy to be approved nearly 30 years ago by the US Food and Drug Administration for the treatment of cancer. Since then, we have learnt the important role of IL-2 in regu...
Finally, we explored other mutations, orientation, and linkers to generate a potent, selective molecule with drug-like manufacturability. These structure activity relationship efforts culminated in the generation of PT101, a mutant IL-2 Fc fusion that was selective in activating and expanding Tregs. ...
Use of a human interleukin-2 mutein (hIL-2 mutein), which is numbered corresponding to the natural type of hIL-2 and which has an amino acid substitution in at least one of positions 20, 88 or 126, for the production of a drug for the treatment and / or prophylaxis of an autoimmune...
Serum PT101 levels and antidrug antibody were assessed. Changes in mononuclear cell populations were measured in peripheral blood by flow cytometry.56 subjects were administered PT101 or placebo. All subjects completed the study. There were no deaths, serious adverse events, dose limiting toxicities,...
et al. Human IL-2 mutein with higher antitumor efficacy than wild type IL-2. J. Immunol. 190, 6230–6238 (2013). Article CAS Google Scholar Tagaya, Y., Bamford, R. N., DeFilippis, A. P. & Waldmann, T. A. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways ...
RG7835 (Roche)is a bivalent conjugate of human IL-2 mutein (T3A, N88D, C125A) and a human IgG1 with abolished binding to Fcγ receptors. Due to its reduced affinity to IL-2Rβγ, IgG-(IL-2N88D)2has a 6–9-fold reduced ability to stimulate Tregin human whole blood pSTAT5 act...