et al. OBX-115, an interleukin 2 (IL2)-sparing engineered tumor-infiltrating lymphocyte (TIL) cell therapy, in patients (pts) with immune checkpoint inhibitor (ICI)-resistant unresectable or metastatic melanoma. ASCO 2024...
人颗粒溶素(granulysin)ELISA Kit,48T/96T THAYER-MARTIN supplement1( VCT inhibitor combination)蛹虫草(北冬虫夏草、北虫草)(斜面) 公司简介 上海博湖生物科技有限公司(Shanghai Bohu Biological Technology Co., Ltd.,China)是一家生物企业,主要从事免疫学、分子生物学和常规生化试剂的销售。主营产品:生化试剂、...
人细胞凋亡抑制因子(IAP)ELISA试剂盒 Human inhibitor of apoptosis,IAP ELISA试剂盒 人集落刺激因子(CSF)ELISA试剂盒 Human colony-stimulating factor,CSF ELISA试剂盒 人γ干扰素诱导单核细胞因子(MIGF/CXCL9)ELISA试剂盒 Human monocyte interferon gamma inducing factor,MIGF ELISA试剂盒 人干扰素诱导T细胞趋化...
近日,中国海洋大学/青岛海洋科学技术国家实验室研究人员在知名期刊《Cell Death&Disease》上发表了题为“Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine”的研究论文,本研究发现了一种新的非竞争性SIRT6抑制剂—8a,并研究了其在胰腺癌的...
et al. Design of a janus kinase 3 (JAK3) specific inhibitor 1-((2 S,5 R)-5-((7 H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop -2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans. J. Med. Chem. 60, 1971–1993 ...
In some embodiments a combination therapy provides for a synergistic effect, where the combination of the inhibitor of IL-2R desensitization and low dose IL-2 provides an effect that is greater than the sum of either the inhibitor or low dose IL-2 administered as a single agent.C. GARRISON...
CD8+ T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the molecular mechanisms by which CD8+ T cells are triggered to enter an exhausted state remain unclear. Here,
Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models Authors - Shuanglian Wang View Article human J Mol Cell Cardiol Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis....
Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apopto... CD4(+) T cells from patients with human immunodeficiency virus (HIV) infection undergo apoptosis at an increased rate, which leads to their ...
药物类型 抗体 别名 靶点 IL-2Rγ 作用机制 IL-2Rγ抑制剂(白介素-2受体γ亚基抑制剂) 治疗领域 血液及淋巴系统疾病其他疾病 在研适应症 再生障碍性贫血难治性重度再生障碍性贫血 非在研适应症- 原研机构 Regeneron Pharmaceuticals, Inc. 在研机构 ...