4.Merck to Acquire Pandion Therapeutics. Retrieved February 25, 2021, from https://www.businesswire.com/news/home/20210225005318/en/；5.Asher Mullard (2021). Restoring IL-2 to its cancer immunotherapy glory. Nature Reviews Drug Discovery. DOI:https://doi.org/10.1038/d41573-021-00034-6.版...
1. Garcin, G. et al. High efficiency cell-specific targeting of cytokine activity. Nat. Commun.5, 3016 (2014).2. Salmeron, A. et al. Abstract 1723: WTX-124 is an IL-2 pro-drug conditionally activated in tumors and able to induce complete regressions in mouse tumor models. Cancer Res...
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5.Asher Mullard (2021). Restoring IL-2 to its cancer immunotherapy glory. Nature Reviews Drug Discovery. DOI:https://doi.org/10.1038/d41573-021-00034-6
4.https://news.rice.edu/news/2022/drug-factory-implants-eliminate-mesothelioma-tumors-mice 5.https://baike.baidu.com/item/%E7%BB%86%E8%83%9E%E5%9B%A0%E5%AD%90/658581?fr=aladdin 6.https://baike.baidu.com/item/%E7%99%BD%E7%BB%86%E8%83%9E%E4%BB%8B%E7%B4%A0-2/1511047?fr=alad...
[4] Mullard A. Restoring IL-2 to its cancer immunotherapy glory. Nat Rev Drug Discov. 2021. [5] 迈威生物 | mabwell.com [6] 上市公司公告
Expert Opin Drug Saf. 2017 Dec;16(12):1347-1357. doi: 10.1080/14740338.2017.1382472. Epub 2017 Sep 21. PMID: 28929820. [13].Mitra S, Leonard WJ. Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies. J Leukoc Biol. 2018 Apr;103(4):643-655. doi: 10.1002/JLB.2...
渠道方面会open mind,除了医院渠道,对于允许的合适渠道也会做好充分的调研准备。 郁闷的鞋套 2024-04-01 16:49 美国II期,NCT06281678【Studies a U.S. FDA-regulated Drug Product:Yes——$亚盛医药-B(06855)$多学学,所见即所得,不要整天搁那叫着我们是GLOBAL我们是GLOBAL,结果一看状态,还是NO】...
Immunocytokine的作用机制可类比于ADC中的drug,通过将细胞因子和靶向抗体进行融合,形成双功能或多功能抗体细胞因子融合蛋白。通过利用抗体的特异性导向,将细胞因子引导至肿瘤微环境等疾病局部,降低off tumor毒性,扩大细胞因子的治疗窗口。 总结 细胞因子大多体内半衰期短、有严重的剂量限制毒性,先前IL-2领域头部玩家大败于...
Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN- gamma in patients with delayed-type drug hypersensitivity. Allergy 2009;64:1269-78.Lochmatter P, Beeler A, Kawabata TT, Gerber BO, Pichler WJ. Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in ...