摘要 Tissues are exposed to diverseinflammatorychallenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an innate ...
& Wouters, C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages. Blood 105, 1648–1651 (2005). 发布于 2024-08-14 15:59・IP 属地湖北...
Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important...
Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-γ inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important...
Free IL-18 causes macrophage activation syndromeWe review newly discovered monogenic immune-dysregulatory disorders that were reported in Pubmed over the last year. Fourteen novel monogenic immune-dysregulatory disorders that present with innate and acquired/adaptive immune dysregulation and inflammatory ...
122-03rmGM-CSF重组鼠粒细胞-巨噬细胞集落刺激因子"Recombinant Murine Granulocyte- Macrophage Colony Stimulating Factor "5μg "123-01 "rmTNF-α重组鼠肿瘤坏死因子-α"Recombinant Murine Tumor Necrosis Factor-alpha "5μg "123-07 "rmLIF重组鼠白血病抑制因子"Recombinant Mouse Leukemia inhibitory factor "...
Distinct roles of IL-18 and IL-1b in murine model of macrophage activation syndrome 细胞因子IL-18和IL-1b 与全身性幼年特发性关节炎及其危及生命的并发症--巨噬细胞活化综合征(MAS)的发病机制有关。Mizuta等人报告的...
can lead to a rapid activation of the monocyte/macrophage system with an upregulation of these cell's innate immune capabilities.1, 17IL-18 itself is induced by stressful stimuli (i.e., bacterial or neurogenic signals).4, 10In this context, it has been proposed that a stress-induced relea...
6Bergsbaken, T., et al. 2007. Macrophage activation redirects yersiniainfected host cell death from apoptosis to caspase1dependent pyroptosis. PLoS Pathog. 3: e161. 7Hsiang, C.Y., et al. 2009. Nuclear factorκB bioluminescence imagingguided transcriptomic analysis for the asse...
随后研究发现,IL一 18 不仅能诱导 T 细胞分泌 IFN ,还能诱导白介素-2 ( IL-2) 、白介素-1 0 ( IL一 1 0) 、共刺 激分子 町. 1、粒细胞 巨噬细 胞集落刺激 因子 ( granulocyte— macrophage colony— stimulating factor,GM— CSF ) 及肿瘤坏死 因子 ( tum or necrosis factor a l pha,TNF—...