7. Billiau, A. D., Roskams, T., Van Damme-Lombaerts, R., Matthys, P. & Wouters, C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages. Blood 105, 1648–...
摘要 Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an inna...
Macrophage Activation Markers Microglia Activation Markers Molecules Secreted by VSMC Multiple Sclerosis and Myelin Related Molecules Neuroinflammatory Factors NOD-like Receptors and the Inflammasome Search Cytokine and Growth Factor Products T Cell Cytokine Signaling ...
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet 2014;46:1140-6.24. Bechman N, Maher J. Lymphodepletion strategies to potentiate adoptive T-cell immunothe...
can lead to a rapid activation of the monocyte/macrophage system with an upregulation of these cell's innate immune capabilities.1, 17IL-18 itself is induced by stressful stimuli (i.e., bacterial or neurogenic signals).4, 10In this context, it has been proposed that a stress-induced relea...
Interleukin-18 (IL-18),an 18 kDa cytokine,is a single,non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12,IL-18 plays an important role...
49.Skeen,M.J.and Ziegler,H.K.(1995)″Activation of gamma delta T cellsfor production of IFN-gamma is mediated by bacteria via macrophage-derivedcytokines IL-1 and IL-12.″J.Immunol.154,5832-41. 50.Trinchieri,G.(1998)″Interleukin-12a cytokine at the interface ofinflammation and immunity...
23. Canna SW, de Jesus AA, Gouni S, et al. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet 2014;46:1140-6. 24. Bechman N, Maher J. Lymphodepletion strategies to potentiate adoptive T-cell immunotherapy - what are we ...
Interleukin-18 (IL-18),an 18 kDa cytokine,is a single,non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12,IL-18 plays an important role...
产品介绍 产品信息 Scientific Data SEC-MALS View Larger Recombinant Human IL-18 (Catalog # 9124-IL) has a molecular weight (MW) of 17.5 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer. Bioactivity View Larger