Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat. Immunol. 15, 938–946 (2014). CAS PubMed PubMed Central Google Scholar Nakajima, S. et al. IL-17A
该研究揭示了IL-17A/CEBPβ/OPN/LYVE-1轴是一种高度免疫抑制级联信号通路,并阐明了OPN分类调控肿瘤相关单核来源巨噬细胞和定居巨噬细胞免疫应答的新机制,为癌症免疫治疗提供了新的靶点。 肿瘤相关巨噬细胞(Tumor-associated macrophage, TAM)通过多种机制促进肿瘤进展。TAM在三阴性乳腺癌患者的肿瘤组织中高度富集,并...
MacrophageMycobacterium terraAutophagy is an important cellular catabolic process for the lysosomal degradation of cytoplasmic organelles, proteins and microorganisms. The autophagic process is intertwined with the immune response: autophagy regulates both innate and adaptive immunity, conversely, cytokines ...
2021年5月,沈玺主任医师在《CELL AND BIOSCIENCE》杂志在线发表题名为“Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy.”—...
除此之外,IL-17A还作用于多种细胞(如巨噬细胞、树突状细胞、成纤维细胞、内皮细胞、上皮细胞、角质形成细胞和淋巴细胞等),释放促炎细胞因子TNF-α、IL-1、IL-6、G-CSF和粒细胞-巨噬细胞集落刺激因子(granulocyte macrophage-colony stimulating factor,GM...
MIP-1α (macrophage inflammatory protein 1α) 巨噬细胞炎症因子1α抗体 0.2ml Mouse IgA 抗小鼠IgA抗体 0.2ml α-MSH/POMC(alpha-melanocyte stimulating hormone) α黑素细胞刺/阿黑皮素原抗体 0.2ml MIP-1β (macrophage inflammatory protein 1β) 巨噬细胞炎症因子1β 抗体 0.1ml ...
We demonstrate an immune cell landscape that switches from a predominantly macrophage population in nondiseased tissue to a T cell–rich environment in disease. Furthermore, we observed a subpopulation of IL-17A–producing T cells capable of inducing profibrotic and inflammatory responses in diseased ...
It has been reported that the release of macrophage-related cytokines, including IL-1, TNF-α and IL-6, is prompted by IL-17A to propagate and amplify the inflammatory onset [44]. Indeed, IL-17A induces monocyte adhesion, increasing the release of intercellular adhesion molecule-1 (ICAM-1)...
tissue inflammation and insulin resistance. In this case, IL-17A antibody and C/EBPβ inhibitor can significantly alleviate BPA-induced adipose tissue macrophage polarization and adipose tissue inflammation, and improve insulin resistance in vivo. This study elucidates that the adipose tissue macrophage ...
1. 2. 6 肺泡巨噬细胞的分离、纯化、培养 行右肺支气管肺泡灌洗收集 BALF,将细胞悬液用含 100 mL/L 小牛血清的RPMI1 0 培养液在培养瓶中经 37℃ 、50 mL / L CO2的细胞培养箱内孵育纯化 3 h,弃培养液,将贴壁纯化的肺泡巨噬细胞( alveolar macrophage,AM) 再分别用 DMEM 进行培养。两组AM 均采用...