摘要 Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an inna...
& Wouters, C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages. Blood 105, 1648–1651 (2005). 发布于 2024-08-14 15:59・IP 属地湖北...
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. Curr Drug Targets Inflamm Allergy 2: 131-136, 2003.Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T et al.: Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. Curr Drug Targets Inflamm ...
Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-γ inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important...
Interleukin-18 (IL-18), an 18 kDa cytokine, is a single, non-glycosylated polypeptide chain containing 157 amino acids. IL-18 was previously known as interferon-g inducing factor (IGIF). This pleiotropic cytokine is produced by monocyte/macrophage cells. Like IL-12, IL-18 plays an important...
These include autosomal-dominant gain-of function mutations in viral innate immune sensors or their...doi:10.1038/nrrheum.2018.11Liesbet LiebenNature Reviews Rheumatology
Distinct roles of IL-18 and IL-1b in murine model of macrophage activation syndrome 细胞因子IL-18和IL-1b 与全身性幼年特发性关节炎及其危及生命的并发症--巨噬细胞活化综合征(MAS)的发病机制有关。Mizuta等人报告的...
newly secreted IFN-gamma can now stimulate monocytes/macrophages to increase their ICE activity. In the presence of continued IL-18 production, increased ICE activity probably results in more processed IL-18, which leads to more lymphocyte IFN-gamma production, which leads to more macrophage ICE ac...
随后研究发现,IL一 18 不仅能诱导 T 细胞分泌 IFN ,还能诱导白介素-2 ( IL-2) 、白介素-1 0 ( IL一 1 0) 、共刺 激分子 町. 1、粒细胞 巨噬细 胞集落刺激 因子 ( granulocyte— macrophage colony— stimulating factor,GM— CSF ) 及肿瘤坏死 因子 ( tum or necrosis factor a l pha,TNF—...
ZY060Mu012 巨噬细胞炎性蛋白相关蛋白1(MRP1)重组蛋白 Recombinant Macrophage Inflammatory Protein Related Protein 1 (MRP1) Mus musculus (Mouse) ZY060Mu021 白介素13(IL13)重组蛋白 Recombinant Interleukin 13 (IL13) Mus musculus (Mouse) ZY060Po011 白介素13(IL13)重组蛋白 Recombinant Interleukin 13...