[9]Wilson SC, Caveney NA, Yen M, et al. Organizing structural principles of the IL-17 ligand-receptor axis. Nature. 2022;609(7927):622-629. [10]Liu S, Song X, Chrunyk BA, et al. Crystal structures of interleu...
[2] Baker, Kevin James, Elizabeth Brint, and Aileen Houston. "Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/IL-23 axis." British Journal of Cancer 128.5 (2023): 735-747. [...
IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy. Virchows Arch. 2013;462:219-28.Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, et al. IL-17A receptor expression differs between subclasses of ...
文章称这类分子为PPI modulator,从功能上讲是阻断IL-17A与IL-17RA的结合,所以也可以称为inhibitor或者antagonist。 至于如何起到阻断作用,是因为结合小分子的IL-17A dimer与正常的dimer构象有些不同,从而不再适合结合receptor。比如下图 (Table 6) 比较的两个指标,一个是A、B链L120 α碳之间的距离,一个是pocke...
IL-17A可促进关节中核因子κB配体的受体激活因子(receptor activators of nuclear factor kappa-B ligand,RANKL)的表达,RANKL与破骨细胞前体细胞表面的受体结合,增加破骨细胞活性。滑膜中的单核细胞作为破骨细胞的前体细胞,当暴露于巨噬细胞集落刺激因子(macrop...
aWhat's that heart mark? 什麼是那個心臟標記?[translate] aAMEC AMEC[translate] aTHE CONVERSATION 交谈[translate] a2. The IL-17A receptor 2. IL-17A感受器官[translate]
相关研究结果近期发表在Science Immunology期刊上,论文标题为“Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation”。论文通讯作者为清华大学医学院董晨(Chen Dong)教授。 这些研究人员在牛皮癣模型中发现IL-17RA/IL-17RD复合物在驱动IL-17...
在一项新的研究中,来自中国清华大学、华东师范大学和同济大学等研究机构的研究人员鉴定出第二个由IL-17RA 和IL-17RD 组成的IL-17R复合物(IL-17RA/IL-17RD),该复合物是由皮肤角质细胞表达的。相关研究结果近期发表在Science Immunology期刊上,论文标题为“Interleukin-17 receptor D constitutes an alternative recep...
recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
1、Goepfert, A., S. Lehmann, J. Blank, F. Kolbinger, and J. M. Rondeau. 2020. Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling, IMMUNITY, 52: 499-512 e5. doi: 10.1016/j.immuni.2020.02.00...