1.1 实验动物及分组 IL-17A全身性基因敲除(generic IL-17A gene knockout,IL-17AKO)小鼠及其同窝野生型(wild-type,WT)小鼠购自Cyagen赛业生物公司(中国成都),SPF级,共33只,为C57BL/6J背景,6～8周龄,20～26 g,雌鼠23只,雄鼠10只。在...
IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritisArthritisPsoriaticArthritisAutoimmuneDiseasesBackground Psoriatic arthritis (PsA) is a chronic inflammatory disease characterised by clinical features that include bone loss and epidermal hyperplasia. Aberrant ...
参考文献 [1] Kong Chen and Jay K. Kolls. Interluekin-17A (IL17A). Gene. 2017 May 30; 614: 8–14. [2] Alcorn JF, Crowe CR, Kolls JK. TH17 cells in asthma and COPD. Annu Rev Physiol. 2010;72:495–516. [3] Balasa R, Bajko Z, Hutanu A....
17A 基因敲除小鼠随机分为对照组㊁N a F 组㊁K O+N a F 组㊂同时,运用H E 染色观察肝的组织形态变化,并通过E L I S A ㊁流式细胞术㊁免疫组化检测肝中炎症细胞㊁炎症因子㊁凋亡的变化情况㊂结果显示,氟暴露诱导了肝组织结构损伤,增加了肝中炎症因子(T N F -α㊁I L -17A ㊁I N...
产品名称:Marmoset IL17A/IL-17A/IL17 Gene Lentiviral ORF cDNA expression plasmid, C-GFPSpark tag 基因靶点:IL17 分子别称:CTLA-8,CTLA8,IL-17,IL-17A,IL17 义翘神州还可以提供高质量的重组蛋白和抗体制备、生产服务,拥有多种重组蛋白表达系统,包括原核蛋白表达系统、酵母蛋白表达系统、昆虫细胞蛋白表达系统(...
2、在包括银屑病、脊柱关节炎、类风湿性关节炎和多发性硬化在内的许多自身免疫性疾病中观察到il-17a分泌增加的异常自身免疫性反应(gene[基因](2017)614:8-14)。这些疾病的一种潜在治疗方法是开发il-17a抑制剂。目前,几种靶向il-17a的单克隆抗体获得fda批准,用于治疗中度至重度斑块型银屑病(expert opin.biol.ther...
[26] Li Yanshuang,et al."In vivo anti-tumor mechanism of mouse colon cancer cells transfected with IL-17 gene." Chinese Journal of Immunology 31.5 (2015). 643-649. [27] Wang, Dan,et al."Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal...
(-197G/A), located at a position -197 from the starting codon of the IL-17A gene, may regulate the expression of messenger ribonucleic acid (mRNA).19 Recently, Kawaguchi et al reported that IL-17F (7488T/C) causes a histidine (His)-to-arginine (Arg) substitution at amino acid ...
A pro-inflammatory cytokine, IL-17A, is associated with increased risk of developing numerous cancers, including non-small cell lung cancer (NSCLC). IL - 17A is a target gene for miR-9. This encouraged us to analyze these two genes in terms of their usefulness as prognostic markers in ...