The present invention relates to an antagonist of interleukin-17B receptor (IL-17RB) which features interruption of the interaction of IL-17RB and MLK4. The present invention also relates to use of such antagonist for treatment of diseases or disorders associated with IL-17RB activation. Further...
The IL-17-mediated signaling pathways have several similarities and differences with the Toll-like receptor (TLR)/IL-1R signaling pathway. Although the two are homologous, Act1 functions differently in these two pathways. Act1 is an unused adapter in the TLR/IL-1R family but is an essential ...
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl Acad. Sci. USA 100, 5986–5990 (2003). Article CAS PubMed PubMed Central Google Scholar Ye, P. et al. Requirement of ...
文章称这类分子为PPI modulator,从功能上讲是阻断IL-17A与IL-17RA的结合,所以也可以称为inhibitor或者antagonist。 至于如何起到阻断作用,是因为结合小分子的IL-17A dimer与正常的dimer构象有些不同,从而不再适合结合receptor。比如下图 (Table 6) 比较的两个指标,一个是A、B链L120 α碳之间的距离,一个是pocke...
Because IL-17A and IL-17F, ligands for IL-17 receptor antagonist (IL-17RA), have been shown to mediate neutrophil migration into the lung in ... CR Crowe,K Chen,DA Pociask,... - 《Journal of Immunology》 被引量: 420发表: 2009年 Enhanced production of IL-17A in patients with severe...
IL-1虽未广泛用于人体研究,但其对免疫系统的特殊作用使它在临床应用方面具有诱人的前景。另外,由于IL-1也参与机体的多种病理过程,所以研究IL-1抑制物可能也具有实际意义。现已克隆出IL-1受体拮抗剂(IL-1 receptor antagonist,IL-1RA),该物质可在体内外封闭IL-1的活性,是一种较理想的IL-1封闭因子。
CASPubMedPubMed CentralGoogle Scholar Akitsu, A. et al. IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells.Nat. Commun.6, 7464 (2015). CASPubMedGoogle Scholar...
IL-23 and IL-12/23 inhibitors (furthest upstream) require maintenance dosing every 8–12 weeks, whereas maintenance dosing with approved IL-17A inhibitors (midstream) is required every 4 weeks, and the IL-17 receptor A antagonist brodalumab (furthest downstream) is adminis- tered every 2 weeks...
management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of th...
上海玉博生物科技有限公司 主要致力于“IL-1 Receptor Antagonist (human) Recombinant Protein Pierce-RP75579”的生产销售。多年的“IL-1 Receptor Antagonist (human) Recombinant Protein Pierce-RP75579”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我