receptor familyimmunoregulationrheumatoid arthritisIL-17 was identified a decade ago as a pro-inflammatory cytokine produced by activated T cells that stimulates the secretion of other cytokines from various non-lymphoid cells by acting through a unique cell surface receptor, IL17R. Evidence that IL-...
IL-17 cytokine and receptor families. IL-17 family comprises six cytokines. The IL-17 receptor family consists of five distinct receptors that share the SEFIR domain, a cytoplasmic motif. IL-17RA is the common subunit for all the receptors, and the CBAD domain is unique to IL-7RA. Differ...
近日,来自清华大学的董晨研究组在著名国际学术期刊immunity在线发表了他们关于白介素17家族成员IL-17B和IL-25在结肠炎及其他免疫相关疾病中发挥不同作用的最新研究进展,他们发现IL-17B和IL-25在结肠炎中扮演了不同角色:IL-17B具有抗炎保护作用,而IL-25则具有致病性。这项研究对于深入了解IL-17家族不同成员的功能...
IL-17 receptor C (IL-17 RC; also known as IL-17 RL and IL-17 Rhom) is an 85-110 kDa member of the IL-17 receptor family. This is one of five families that currently comprise the cytokine receptor superfamily (1-6). At this time, there are five members within the IL-17 recepto...
The key IL-17 family members are IL-17A and IL-17F, which share a 50% sequence homology. They bind to an IL-17 receptor (IL-17R) complex that is composed of two chains, known as IL-17RA and IL-17RC. IL-17A and IL-17F interact with inflammatory cytokines such as IL-1 and tum...
The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species,...
2022年7月21日,K. Christopher Garcia课题组在Nature上发表了题为Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis的文章,通过解析IL-25—IL-17RB(无信号介导复合物)和IL-25—IL-17RB—IL-17RA(有信号介导复合物),阐释了IL-25可以通过别构调节三元复合物的形成来介导信号传递,IL-17...
IL-17 receptor C (IL-17RC; also known as IL-17RL and IL-17 Rhom) is an 85‑110 kDa member of the IL-17 receptor family. This is one of five families that currently comprise the cytokine receptor superfamily (1, 2, 3, 4, 5, 6). At this time, there are five members within...
[25]Liu S, Song X, Chrunyk BA, Shanker S, et al. Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nature communications. 2013 May 21;4(1):1888. [26]Brembilla NC, Senra L, Boehncke WH. The IL-17 family of cytokines in psoriasis: IL-17A and beyond....
The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other...