Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17 (T(H)17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease. IL-17A and its receptor (IL-17RA) are the ...
IL-17家族如何在细胞外侧与其受体结合来介导信号传递仍是需要通过结构生物学手段来解决的问题。 2022年7月21日,K. Christopher Garcia课题组在Nature上发表了题为Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis的文章,通过解析IL-25—IL-17RB(无信号介导复合物)和IL-25—IL-17RB—IL-...
[25]Liu S, Song X, Chrunyk BA, Shanker S, et al. Crystal structures of interleukin 17A and its complex with IL-17 receptor A. Nature communications. 2013 May 21;4(1):1888. [26]Brembilla NC, Senra L, Boehncke WH. The IL-17 family of cytokines in psoriasis: IL-17A and beyond....
1. N. C. Brembilla, L. Senra, W. H. Boehncke, The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond. Front Immunol 9, (2018). 2. J. Huang et al., Interleukin-17D regulates group 3 innate lymphoid cell fu...
(D, E) Effect of CARHSP1 knockdown on the expression of IL-17 receptor family members IL-17RA, IL-17RB and IL-17RC in 22Rv1 and PC-3 cells, as detected by RT-qPCR (n = 3, mean ± SD). 18 S was used as an internal loading control. (F) Western blotting analysis ...
The key IL-17 family members are IL-17A and IL-17F, which share a 50% sequence homology. They bind to an IL-17 receptor (IL-17R) complex that is composed of two chains, known as IL-17RA and IL-17RC. IL-17A and IL-17F interact with inflammatory cytokines such as IL-1 and tum...
Both need to bind to the common receptor IL-17RA to start signal transduction. The homology of IL-17B-E and IL-17 A could be better. There are five members in the IL-17 receptor family: IL-17R/IL-17RA, IL-17B R/IL-17RB, IL-17RC, IL-17RD/SEF and IL-17RE. IL-17 family ...
背景资料Interleukin-17A is a protein that in humans is encoded by the IL17A gene.This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells.IL-17A-mediated downstream pathways...
21 This general lack of receptor family identity also carries over into the cytoplasmic region as there is no identifiable tyrosine kinase homology region(s). There are, however, acidic and serine-rich regions that are similar to regions found in the IL-2 R beta chain, the IL-4 R and ...
IL-17 cytokine and receptor families. IL-17 family comprises six cytokines. The IL-17 receptor family consists of five distinct receptors that share the SEFIR domain, a cytoplasmic motif. IL-17RA is the common subunit for all the receptors, and the CBAD domain is unique to IL-7RA. Differ...