IL-17在促进银屑病、银屑病关节炎和强直性脊柱炎(AS)等自身免疫疾病中起重要作用。目前全球范围内共上市5款靶向IL-17/IL-17R的大分子生物药,包括4个IL-17单抗和1个IL-17RA单抗,分别是诺华的Secukinumab、礼来的Ixekizumab、Biocad的Netakimab、协和发酵...
The IL-17 family of cytokines in psoriasis: IL-17A and beyond. Frontiers in immunology, 9, p.1682. Lauffer, F., Eyerich, K., Boehncke, W.H., Asadullah, K., Beissert, S., Ghoreschi, K. and Schön, M.P., 2020. Cytokines of the IL‐17 family in psoriasis. JDDG: Journal...
近日,来自,哈尔滨医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“The IL-17 family in diseases: from bench to bedside”的文章,该研究综述了白介素17家族在疾病中的作用。 白介素17(IL-17)家族由6个成员(IL-17A-17F)组成,最近发现了与其相关的所有受体。IL-17在大约30年前...
IL-17 cytokine and receptor families. IL-17 family comprises six cytokines. The IL-17 receptor family consists of five distinct receptors that share the SEFIR domain, a cytoplasmic motif. IL-17RA is the common subunit for all the receptors, and the CBAD domain is unique to IL-7RA. Differ...
近日,来自,哈尔滨医科大学的研究者们在Signal Transduction and Targeted Therapy杂志上发表了题为“The IL-17 family in diseases: from bench to bedside”的文章,该研究综述了白介素17家族在疾病中的作用。 白介素17(IL-17)家族由6个成员(IL-17A-17F)组成,最近发现了与其相关的所有受体。IL-17在大约30年前...
IL17样细胞因子似乎形成了一个新的信号分子家族。这些蛋白质在结构上不同于其他免疫调节细胞因子。其受体...
2、 McGeachy MJ, Cua DJ, Gaffen SL: The IL-17 Family of Cytokines in Health and Disease. Immunity 2019, 50(4):892-906. 3、 Onishi RM, Gaffen SL: Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disea...
Gu C, Wu L, Li X (2013) IL-17 family: cytokines, receptors and signaling. Cytokine 64: 477-485.IL-17 family: Cytokines, receptors and signaling[J] . Chunfang Gu,Ling Wu,Xiaoxia Li.Cytokine . 2013 (2)Gu C, Wu L & Li X (2013) IL-17 family: Cytokines, receptors and signaling....
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1. N. C. Brembilla, L. Senra, W. H. Boehncke, The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond. Front Immunol 9, (2018). 2. J. Huang et al., Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. Immunity, (2021). ...