IL-12 receptor. II. Distribution and regulation of receptor expression - Desai, Quinn, et al. - 1992 () Citation Context ... excess IL-12 p40 and favors effector function by the IL-12 heterodimer. Naive T cells lack responsiveness to IL-12 due to a lack of surface expression of the ...
IL12RB1(Interleukin 12 receptor subunit beta 1)是一种细胞膜上的蛋白质,是白细胞介素12(IL-12)信号通路的重要组成部分。本文介绍了IL12RB1多克隆抗体的制备方法、基本信息以及其在生物学研究中的应用。 引言: IL12RB1是IL-12信号通路的关键受体亚单位,它在免疫调节、细胞介导的免疫反应和抗病毒免疫等多个...
Interleukin 12 receptor,IL-12R ELISA试剂盒 规格 96T/48T 保存 2-8°C 服务 提供免费代测,技术咨询。请在线索取说明书 四大优点: 一、高效、灵敏、特异的抗体; 二、稳定的重复性和可靠性; 三、吸附性能好,空白值低,孔底透明度高的固相载体; 四、适用血清、血浆、组织匀浆液、细胞培养上清液、尿液等等多种标...
These IL-12 functions depend on its IL-12 and IL-12receptor complex. IL-12 (interleukin 12) is a heterodimeric pro-inflammatory cytokine that induces the production ofinterferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and forms a link between innateresistance and...
Christopher Garcia研究团队在Cell杂志上发表题为Structural basis for IL-12 and IL-23 shared receptor usage reveals a gateway for shaping actions on T versus NK cells的研究论文,在这篇论文中,作者展示了完整的IL-12和IL-23受体复合物冷冻电镜(Cryo-EM)图谱,IL-12和IL-23受体复合物的结构指导了激活T细胞...
IL-12 receptor subunit beta-1||IL-12R subunit 别名 CD212 其他名 IL-12 receptor beta componentCD_antigen: CD212 From Uniport IL-12 R beta 1/IL12RB1 基因家族蛋白 CD molecules 官方名通用名 CCR2CCR2 protein, recombinant ENGEndoglin/CD105 protein, recombinant ...
We show here that interleukin-12 receptor β1 (IL-12Rβ1)–mediated signaling is important for in vivo Tfh response in humans. Although not prone to B cell-deficient–associated infections, subjects lacking functional IL-12Rβ1, a receptor for IL-12 and IL-23, displayed substantially less ...
IL-12 Receptor β2 (IL-12Rβ2)-Deficient Mice Are Defective in IL-12-Mediated Signaling Despite the Presence of High Affinity IL-12 Binding Sites IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 ...
单克隆抗体与来自非人类灵长类动物的IL-12 (p70) 发生交叉反应。仅供研究使用(RUO)。不用于诊断过程。艾美捷抗人IL-12 (p70)单抗MT704文献参考：Pourakbari, B., et al. (2018). Evaluation of interleukin-12 receptor beta1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG ...