白介素-12受体(IL-12R)ELISA试剂盒 英文名称 Interleukin 12 receptor,IL-12R ELISA试剂盒 规格 96T/48T 保存 2-8°C 服务 提供免费代测,技术咨询。请在线索取说明书 四大优点: 一、高效、灵敏、特异的抗体; 二、稳定的重复性和可靠性; 三、吸附性能好,空白值低,孔底透明度高的固相载体; ...
IL-12Rβ1在T细胞和NK细胞中表达,深入了解IL-12Rβ1与IL-12和IL-23的结合方式或许有助于更深入研究IL-12和IL-23在肿瘤免疫中发挥的不同功能,破解临床应用的瓶颈。近日,来自斯坦福大学医学院的K. Christopher Garcia研究团队在Cell杂志上发表题为Structural basis for IL-12 and IL-23 shared receptor usage ...
IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding ... CY Wu,X Wang,M Gadina,... - 《Journal of Immunology》 被引量: 477发表: 2000年 IL-12 Receptor 2 (IL-12R 2)-Deficient Mice Are...
We show here that interleukin-12 receptor β1 (IL-12Rβ1)–mediated signaling is important for in vivo Tfh response in humans. Although not prone to B cell-deficient–associated infections, subjects lacking functional IL-12Rβ1, a receptor for IL-12 and IL-23, displayed substantially less ...
英文名称: Recombinant Mouse Interleukin-12 receptor subunit beta-2 保质期: 长期 个月 保存条件: 冻干蛋白置于-20℃ 特别提示:包括重组小鼠IL-12RB2在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!产品名称:重组小鼠IL-12RB2英文名称:Recombinant Mouse Interleukin-12 receptor su...
Glassman, C.R.; Mathiharan, Y.K.; Jude, K.M.; Su, L.; Panova, O.; Lupardus, P.J.; Spangler, J.B.; Ely, L.K.; Thomas, C.; Skiniotis, G.; et al. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cel...
Enables identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of lymphocyte pro...
Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that are produced by antigen-presenting cells to regulate the activation and differentiation of lymphocytes, and they share IL-12Rβ1 as a receptor signaling subunit. We present a crystal structure of the quaternary IL-23 (IL-23p19/...
(BMDCs) to low concentrations of a variety ofelectrophilicNrf2 activators including itaconate prior to Toll-like receptor (TLR) stimulation inhibits transcription of pro-inflammatory cytokines (such as interleukin [IL]-12 and IL-1β) by activation of Nrf2. By contrast, high doses of these ...
Armored inducible expression of IL-12 enhances antitumor activity of glypican-3-targeted chimeric antigen receptor-engineered T cells in hepatocellular carcinoma. J. Immunol. 203, 198–207 (2019). CAS PubMed Google Scholar Zhu, M. L., Nagavalli, A. & Su, M. A. Aire deficiency promotes ...