IL-12Rβ1在T细胞和NK细胞中表达，深入了解IL-12Rβ1与IL-12和IL-23的结合方式或许有助于更深入研究IL-12和IL-23在肿瘤免疫中发挥的不同功能，破解临床应用的瓶颈。近日，来自斯坦福大学医学院的K. Christopher Garcia研究团队在Cell杂志上发表题为Structural basis for IL-12 and IL-23 shared receptor usage ...
在缺乏常见的γ细胞因子的情况下,IL-12可以驱动大量NK细胞的扩增,NK细胞的成熟,参与记忆NK细胞的发育,用IL-12、IL-18和低剂量IL-15治疗,可诱导长寿NK细胞。 IL-12的激活受到IL-18R(不属于IL-12R家族),而它不属于IL-12R家族。IL-12和IL-18都可以由DC同时产生。IL-12和IL-18增强了NK细胞的效应功能,包括IF...
白介素-12受体(IL-12R)ELISA试剂盒 英文名称 Interleukin 12 receptor,IL-12R ELISA试剂盒 规格 96T/48T 保存 2-8°C 服务 提供免费代测,技术咨询。请在线索取说明书 四大优点: 一、高效、灵敏、特异的抗体; 二、稳定的重复性和可靠性; 三、吸附性能好,空白值低,孔底透明度高的固相载体; 四、适用血清、...
IL-1α和IL-1βb 的生物活性由 IL-1R1(IL-1 type I receptor)介导,结合诱导 IL-1R1 胞外区构象变化,使其与 IL-1RAcP 相互作用,IL-1RAcP 是细胞内信号传导所必需的。 图片来源于文献:Structural Basis of IL-1 Family Cytokine Signaling 图1 . IL-1信号通路图 IL-10 通路 IL-10家族中有9个成员...
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management and monitoring of the interleukin-1 mediated autoinflammatory diseases: cryopyrin-associated periodic syndromes, tumour necrosis factor receptor-associated periodic syndrome, mevalonate kinase deficiency, and deficiency of th...
We show here that interleukin-12 receptor β1 (IL-12Rβ1)–mediated signaling is important for in vivo Tfh response in humans. Although not prone to B cell-deficient–associated infections, subjects lacking functional IL-12Rβ1, a receptor for IL-12 and IL-23, displayed substantially less ...
Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box. Cytokine Growth Factor Rev. 2016 Dec;32:3-15. doi: 10.1016/j.cytogfr.2016.04.002. Epub 2016 Apr 30. PMID: 27165851. [12].Karo-Atar D, Bitton A, Benhar I, Munitz A. Therapeutic...
IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding ... CY Wu,X Wang,M Gadina,... - 《Journal of Immunology》 被引量: 485发表: 2000年 IL-12 Receptor 2 (IL-12R 2)-Deficient Mice Are...
Antibodies to the IL-12 Receptor β2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In Vivo Great attention has been placed on the possibility of distinguishing Th1 from Th2 cells on the basis of differential expression of surface receptors. We have recently shown that the differential...