· Regulatable interleukin-12 gene therapy in patie.nts with recurrent high-grade glioma: Results of a phase 1 trial.Sci Transl Med. 2019 Aug 14;11(505):eaaw5680. · Advances in interleukin-12 gene therapy for acquired liver diseases. Curr Gene Ther. 2009 Apr;9(2):62-71. · Regulati...
3.Chiocca EA, Yu JS, Lukas RV, et al. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. Aug 14 2019;11(505)doi:10.1126/scitranslme...
3.Chiocca EA, Yu JS, Lukas RV, et al. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. Aug 14 2019;11(505)doi:10.1126/scitranslmed.aaw5680 本期译者 北京协和医院神经外科,北京协和医学院医学培养模式改革试点班2...
2000. IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic pathology . Eur. J. Immunol . 30 :834–839Satoskar, A. R., S. Rodig, S. R. Telford, A. A. Satoskar, S. K. Ghosh, F. von Lichtenberg, and J. R. David. 2000. IL-...
(tavo; pIL-12):intratumoral tavokinogene telseplasmid 抗体细胞因子IL-12融合 NCT04471987,研发单位Philogen S.p.A.,Safety and Early Signs of Efficacy of IL12-L19L19. (DODEKA) 喵评 IL-12家族有多个成员,其中IL-12促进TH1分化,抗肿瘤为主要关注点。IL-...
这些结果还提示着这种治疗可能延长患者的生存期。相关研究结果发表在2019年8月14日的Science Translational Medicine期刊上,论文标题为“Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial”。
IL-35包含p35和EBI3(Epstein-Barr virus-induced gene 3)亚基,受体由IL-12Rβ2和gp130组成。gp130是IL-6家族的共享受体亚基。 IL-35是由Tregs和Bregs产生, 通过抑制作用在免疫调节中发挥作用,可以抑制Th17细胞的效应功能。与IL-12细胞因子家族的其他成员(IL-12、IL-23、IL-27和IL-39)诱导Th细胞产生IFN-γ...
2006被聘为郑州大学河南省肿瘤病毒基因治疗学科特聘教授,任中英分子肿瘤学研究中心执行主任兼科技主管,郑州大学“211重点学科”肿瘤生物治疗学术带头人;Gene Therapy和Molecular Therapy-Oncolytics杂志国际编委;在Nature Biotechnology、Journal of Clinical Investigation等杂志发表学术论文60余篇,总影响因子超过260,被引用超过...
AIM: To explore whether an adenoviral vector expressing the interleukin-12 (IL-12) gene (AdvIL-12) can induce a strong anti-hepatic carcinoma effectin vitro. METHODS: HepG2 cells transfected with AdvIL-12 were cultured as the experimental group, and cells transfected with Adv-GFP or non-tran...
Key words IL-12 Dendritic cells Gene transfection Cancer vaccine Th1/Th2 differentiation IL-12通过增强特异性与非特异性细胞免疫应答,而成为一种有效的抗肿瘤、抗感染免疫的生物佐剂[1],但其全身应用毒性严重。因此,寻找合适的应用途径具有重要的临床意义。我们以前对p53蛋白的一些多肽抗原表位研究显示:p53264-272...