· Regulatable interleukin-12 gene therapy in patie.nts with recurrent high-grade glioma: Results of a phase 1 trial.Sci Transl Med. 2019 Aug 14;11(505):eaaw5680. · Advances in interleukin-12 gene therapy for acquired liver diseases. Curr Gene Ther. 2009 Apr;9(2):62-71. · Regulati...
3.Chiocca EA, Yu JS, Lukas RV, et al. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. Aug 14 2019;11(505)doi:10.1126/scitranslme...
3.Chiocca EA, Yu JS, Lukas RV, et al. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. Aug 14 2019;11(505)doi:10.1126/scitranslmed.aaw5680 本期译者 北京协和医院神经外科,北京协和医学院医学培养模式改革试点班2...
The product from VNTANST-IL-12 fusion gene therapy increased accumulation of IL-12 in the environment, and in three models, VNTANST-IL-12 gene therapy inhibited distal . In a spontaneous model, inhibition of was improved compared to wild-type IL-12...
(tavo; pIL-12):intratumoral tavokinogene telseplasmid 抗体细胞因子IL-12融合 NCT04471987,研发单位Philogen S.p.A.,Safety and Early Signs of Efficacy of IL12-L19L19. (DODEKA) 喵评 IL-12家族有多个成员,其中IL-12促进TH1分化,抗肿瘤为主要关注点。IL-...
这些结果还提示着这种治疗可能延长患者的生存期。相关研究结果发表在2019年8月14日的Science Translational Medicine期刊上,论文标题为“Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial”。
IL-35包含p35和EBI3(Epstein-Barr virus-induced gene 3)亚基,受体由IL-12Rβ2和gp130组成。gp130是IL-6家族的共享受体亚基。 IL-35是由Tregs和Bregs产生, 通过抑制作用在免疫调节中发挥作用,可以抑制Th17细胞的效应功能。与IL-12细胞因子家族的其他成员(IL-12、IL-23、IL-27和IL-39)诱导Th细胞产生IFN-γ...
2006被聘为郑州大学河南省肿瘤病毒基因治疗学科特聘教授,任中英分子肿瘤学研究中心执行主任兼科技主管,郑州大学“211重点学科”肿瘤生物治疗学术带头人;Gene Therapy和Molecular Therapy-Oncolytics杂志国际编委;在Nature Biotechnology、Journal of Clinical Investigation等杂志发表学术论文60余篇,总影响因子超过260,被引用超过...
IL-12具有显著的免疫激活和肿瘤控制作用,但在诱导抗肿瘤作用所需的剂量下会引起严重的不良反应。然而,靶向给药策略使IL-12在肿瘤部位达到高浓度,同时避免全身反应,又激发了人们对IL-12在癌症治疗的兴趣。 基因治疗可以更好地控制治疗方案中白介素的定位和数量。Tavokinogene telseplasmid是一种IL-12编码质粒,电穿...
Rabbit Anti-IL12 Polyclonal AntibodyDATASHEET Host:Rabbit Target Protein:IL12 IR:Immunogen Range:51-150/219 Clonality:Polyclonal Isotype:IgG Entrez Gene:3592 Swiss Prot:P29459 Source:KLH conjugated synthetic peptide derived from human IL-12:51-150/219 Purification:affinity purified by Protein A St...