BioNTech与罗氏子公司Genentech联合开发的Autogene cevumeran(代号BNT122)是一种基于尿苷信使 RNA 脂质复合物(RNA–LPX)的个性化新抗原特异性免疫疗法(iNeST)。由最多两个 5′加帽的单链尿苷 mRNA 分子组成,通过短的GS linker连接,每个分子编码多达 10 个新抗原,总共可编码多达 20 个新抗原。 这些新抗原候选物是...
Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation. Bone Marrow Transplant. 41, 821–826 (2008). Article CAS PubMed Google Scholar Gruhn, B. et al. Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 ...
作为一种模式识别受体,RIG‑I含有RNA解旋酶结构域和 两个N端胱天蛋白酶募集结构域(CARD),所述结构域将信号传达至下游信号传导接头分子 MAVS(线粒体抗病毒信号传导蛋白)。RIG‑1经由MAVS进行信号传导引起了多种反应,包括经 由TBK1和IRF7/8诱导I型IFN反应,包括IFNα和IFNβ,以及活化胱天蛋白酶‑8依赖性...
HIV-1 infection elicits a broad range of host responses, many of which interfere with the regulatory pathways of gene expression of interleukin-12 (IL-12), a heterodimeric cytokine essential for cell-mediated immunity against microbial infection. The inhibition of IL-12 production by accessory cells...
The gene expression levels were calculated by the relative standard curve method. The primers used for qPCR in this study are listed as follows: IL-12p35: 5ʹ-ACGAGAGTTGCCTGGCTACTAG-3ʹ and 5ʹ-CCTCATAGATGCTACCAAGGCAC-3ʹ; IL-12p40: 5ʹ-CAGAAGCTAACCATCTCCTGGTTTG-3ʹ and ...
The cardiac gene expression for collagen lysyl oxidase-like protein 3 (LOXL3) increased 9.1-fold as well as LOX increased 1.7-fold. Conclusions: This study demonstrates that stimulation of DC TLR 9 receptor polarizes T-lymphocyte to TH1 which mediates the up-regulation of LOX activity and ...
IL-27 is a heterodimer made up of IL-27p28 and Epstein Barr virus induced gene 3 (EBI3) subunits [10], [62]. IL-27p28 has also been shown to be expressed as a monomer, which can inhibit IL-6, IL-27 and IL-11 signalling through the common gp130 signalling receptor [63], [...
Gruhn, B. et al. Polymorphism of interleukin-23 receptor gene but not ofNOD2/CARD15is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children.Biol. Blood Marrow Transplant.15, 1571–1577 (2009). ...
UNSPSC 21.039121400 Approvals cULus Recognized Approval ID: E60425-19931014 VDE Zeichengenehmigung Approval ID: 40050648 Environmental product compliance EU RoHS Fulfills EU RoHS substance requirementsYes(No exemptions) China RoHS Environment friendly use period (EFUP)EFUP-E ...
SK 3,81/2,8:FORTL.ZAHLEN-Marker card0804109 FMC 1,5/12-ST-3,5-RF-PCB connector1952128 Your advantages Designed for integration into the SMT soldering process Intuitive locking mechanism prevents accidental disconnection Vertical connection enables multi-row arrangement on the PCB ...