Recently, more refined approaches have emerged including next generation IL-2 variants44,45,46, antibodies that stabilize IL-2 in a conformation that favours Treg expansion47, gene-engineered T cells expressing orthogonal IL-2 and IL-2-receptor pairs48, CD25-biasing anti-IL-2 antibodies49 and ...
While Aβ42and tau remain the predominant targets for the treatment of AD, another candidate gene is Pin1. Pin1 is the only known peptidyl-prolyl isomerase responsible for thecistotransortranstocisconversion of the peptide bond between a phosphorylated Ser or Thr and adjacent, C-terminal Pro [...
While Aβ42and tau remain the predominant targets for the treatment of AD, another candidate gene is Pin1. Pin1 is the only known peptidyl-prolyl isomerase responsible for thecistotransortranstocisconversion of the peptide bond between a phosphorylated Ser or Thr and adjacent, C-terminal Pro [...
Even tumors that are poorly immuno- genic can be recognized by MHC class I-restricted CD8+ cytotoxic T cells, if the tumor cells are en- gineered to harbor the IL-2 gene. However, tumor cells engineered to produce cytokines have unex- pected side effects (Dranoff et al., 1993; ...
til the ability to self-stimulate the proliferation of il-2 gene transfection. 翻译结果2复制译文编辑译文朗读译文返回顶部 翻译结果3复制译文编辑译文朗读译文返回顶部 TIL transfected with IL-2 gene in ways that can be self-stimulate proliferation of capabilities. ...
(encoded by theBcl2l11gene). We irradiated B6.Rag1–/–mice and injected wild-type,Bcl2l11–/–,Card11unm/unmorIl2rb–/–BM to reconstitute haematopoiesis. These chimeras were examined 5 days after EdU injection, which is when EdU+ CCR7+ Helios+ Foxp3– thymocytes peak and EdU+ CCR7+...
Glas J,T?r?k HP,Unterhuber H, et al.The -295T-to-C promoter polymorphism of the IL-16 gene is associated with Crohn‘s disease.Clinical Immunology. 2003Glas,J. et al. (2003) The -295T-to-C promoter polymorphism of the IL-16 gene is associated with Crohn's disease. Clin. ...
随着广谱抗生素、免疫抑制剂、糖皮质激素、化疗药物等在临床上的广泛应用以及器官移植、机械通气等生命支持技术的开展,深部真菌感染率呈增长趋势,而肺部由于直接与大气相通,且全身血流均经过肺循环,所以与其他器官相比,在深部真菌感染中侵袭性肺部真菌感染(invasivepulmonaryfungalinfections,IPFI)最为常见。IPFI多发生在有...
Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene Inflamm Res, 52 (2003), pp. 272-276 10.1007/s00011-003-1170-z PubMed PMID: 12835899 CrossrefView in ScopusGoogle Scholar 25 SJ Oh, JH Kim, DH Chung NOD2-mediated suppression of CD55 on neutrophils enhances C5a...
However, alternative pathways are able to release active IL-1β via the inflammasomes NLRP1, NLRC4 (NLR family CARD domain-containing protein 4) and AIM2 (absent in melanoma 2) [126], caspase-8 and other enzymes [127,128,129,130,131,132], with reduced efficiency. Thus, in contrast ...