In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and ...
[1]Ouyang W, O’Garra A. IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation. Immunity. 2019 Apr 16;50(4):871-91. [2]Sabat R. IL-10 family of cytokines. Cytokine & growth factor reviews. 2010 Oct 1;21(5):315-24. [3]Burmeister AR, Marriott I....
引自:1. OuyangW, O'Garra A. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science toClinical Translation. 由于IL-10作为一种免疫抑制细胞因子被广泛接受,IL-10被认为通过降低肿瘤微环境中的抗肿瘤免疫反应来促进肿瘤免疫逃逸。但是,TakashiTanikawa研究发现[7],IL-10基因对于肿瘤也有一定的抑制效果...
图6 在肿瘤免疫中,IL-10促进和抑制肿瘤的免疫机制 引自:1. OuyangW, O'Garra A. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science toClinical Translation. 由于IL-10作为一种免疫抑制细胞因子被广泛接受,IL-10被认为通过降低肿瘤微环境中的抗肿瘤免疫反应来促进肿瘤免疫逃逸。但是,TakashiTanikaw...
引自:1. OuyangW, O'Garra A. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science toClinical Translation. 由于IL-10作为一种免疫抑制细胞因子被广泛接受,IL-10被认为通过降低肿瘤微环境中的抗肿瘤免疫反应来促进肿瘤免疫逃逸。但是,TakashiTanikawa研究...
1. Babu S, et al. (2015) Interleukin-10 stimulates anti-HIV response through upregulation of dectin-1 in human macrophages. J Immunol, 194(3): p.1525-1537. 2. Ouyang W, et al. (2011) IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation. Immunity, ...
Many viruses encode viral members of the IL-10 family, such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV).Its main function is inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by ...
细胞因子的白细胞介素-10(IL-10)家族中有9个成员,即IL-10、IL-19、IL-20、IL-22、IL-24、IL-26,以及亲缘关系较远的家族成员IL-28A(IFN-λ2)、IL-28B(IFN-λ3)和IL-29(IFN-λ1)。IL-28A、IL-28B和IL-29又称为Ⅲ型干扰素(IFN)。这些细胞因子在感染和炎症过程中调节免疫反应时发挥着不可或缺的...
IL-1 Family orb867311Human IL-1 alpha proteinHEK293 orb257615Human IL-1 beta proteinE. coli or...
引自:1. OuyangW, O'Garra A. IL-10 Family Cytokines IL-10 and IL-22: from Basic Science toClinical Translation. 由于IL-10作为一种免疫抑制细胞因子被广泛接受,IL-10被认为通过降低肿瘤微环境中的抗肿瘤免疫反应来促进肿瘤免疫逃逸。但是,TakashiTanikawa研究发现[7],IL-10基因对于肿瘤也有一定的抑制效果...