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The use of cytokines from the IL-2 family (also called the common 纬 chain cytokine family) such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer patients is one of the most important areas of current cancer immunotherapy research. The infusion ...
2、复溶浓度应大于100 μg/ml. 3、冻干蛋白溶于ddH2O中 4、复溶后根据使用量分装保存,避免反复冻融。 关于IL-2: Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this famil...
4. Ma A, et al. (2019) IL-2 Family Cytokine/Receptor Interactions: A New Therapeutic Target for Immune-mediated Disorders. The Journal of Clinical Investigation, 130(4): 1529-1538.
[9]J. Palomo et al., The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases, Cytokine (2015). [10]Boutin, H., Kimber, I., Rothwell, N. J., & Pinteaux, E. (2003). The Expanding Interleukin-1 Family and Its Receptors: Do Alternat...
图片来源于文献:Structural Basis of IL-1 Family Cytokine Signaling 图1 . IL-1信号通路图 IL-10 通路 IL-10家族中有9个成员,包括IL-10和IL-20亚家族成员IL-19、IL-20、IL-22、IL-24和IL-26;以及其他相关细胞因子IL-28A、IL-28B和IL-29,主要是根据它们的结构相似性、受体和下游信号而被归为一组。
● Fields JK, Günther S, Sundberg EJ. Structural Basis of IL-1 Family Cytokine Signaling. Front Immunol. 2019, 10:1412. ● Xu D, Mu R, Wei X. The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis. Front Immunol. ...
[2] Sabat R. IL-10 family of cytokines. Cytokine & growth factor reviews. 2010 Oct 1;21(5):315-24. [3] Burmeister AR, Marriott I. The interleukin-10 family of cytokines and their role in the CNS. Frontiers in cellular neuroscience. 2018 Nov 27;12:458. ...
● Fields JK, Günther S, Sundberg EJ. Structural Basis of IL-1 Family Cytokine Signaling. Front Immunol. 2019, 10:1412. ● Xu D, Mu R, Wei X. The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis. Front Immunol. 2019, 10:2025...
orthogonal IL-2 的治疗潜力 2018 年在Science期刊发表的论文 “Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes”。研究人员同时改造 T 细胞的共刺激受体 IL-2R 和 IL-2,使得经过改造的 IL-2 只与改造过的 T 细胞 IL-2R 结合,而不与体内其他 T 细胞表面的 ...