参考文献 Charles Anthony Dinarello,The IL-1 family of cytokines and receptors in rheumatic diseases,Nature Reviews Rheumatology,2019 Diana Boraschi,et al,The family of the interleukin-1 receptors,Immunol Rev . 2018 Jan;281(1):197-232 Alberto Mantovani,et al,Interleukin-1 and Related Cytokines i...
主要参考文献: ● Fields JK, Günther S, Sundberg EJ. Structural Basis of IL-1 Family Cytokine Signaling. Front Immunol. 2019, 10:1412. ● Xu D, Mu R, Wei X. The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis. Front Immunol. 2019, 10:2025...
参考文献 Charles Anthony Dinarello,The IL-1 family of cytokines and receptors in rheumatic diseases,Nature Reviews Rheumatology,2019 Diana Boraschi,et al,The family of the interleukin-1 receptors,Immunol Rev . 2018 Jan;281(1):197-232 Alberto Mantovani,et al,In...
主要参考文献: ● Fields JK, Günther S, Sundberg EJ. Structural Basis of IL-1 Family Cytokine Signaling. Front Immunol. 2019, 10:1412. ● Xu D, Mu R, Wei X. The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis. ...
● Fields JK, Günther S, Sundberg EJ. Structural Basis of IL-1 Family Cytokine Signaling. Front Immunol. 2019, 10:1412. ● Xu D, Mu R, Wei X. The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis. Front Immunol. 2019, 10:2025...
IL-1 family cytokines bind to their cognate cell surface receptors and initiate signaling. IL-1, IL-33 and IL-36 bind specific receptors, IL-1R1, ST2, and IL-1Rrp2 respectively. They use IL1RAcP as a co-receptor. The formed complexes trigger intracellular signaling cascades. IL-1 family...
in general pathologyThe TLR and IL-1 signalling network at a glanceA clinical perspective of IL-1b as the gatekeeper of inflammationOverview of the IL-1 family in innate inflammation and acquired immunityPrimer inflammasomes and interleukin 1β in inflammatory disordersRole of inflammatory cytokines ...
IL-1 family of cytokines has important roles in endocrinology and in the regulation of responses associated with inflammatory stress. The IL-1 family consists of two pro-inflammatory cytokines, IL-1伪 and IL-1尾, and a naturally occurring anti-inflammatory agent, the IL-1 receptor antagonist (...
Inthis Review, each of the eleven IL-1 family cytokines and their receptors are discussed, along with their putative roles in rheumatic disease and therapeutic options for targeting or promoting these cytokines.doi:10.1038/s41584-019-0277-8Charles Anthony Dinarello...
[32]Rodriguez-Smith J, Lin YC, Tsai WL, et al. Cerebrospinal Fluid Cytokines Correlate With Aseptic Meningitis and Blood-Brain Barrier Function in Neonatal-Onset Multisystem Inflammatory Disease: Central Nervous System Biomarkers in Neonatal-Onset Multisystem Inflammatory Disease Correlate With Central Ner...