Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an innate im...
IL-18&IL-21: 增强NK细胞毒性作用 Perez, Sonia A等研究发现IL-21的存在显著增加了CB/CD34来源的CD56+细胞的NK细胞毒性。图片来源Perez, Sonia A et al[3].在Strengell, Mari等人的研究中发现，将IL-21与IL-15或IL-18协同作用，能够增强人NK细胞和T细胞中IFN-γ的产生，从而更大程度上发挥细胞毒作用。图...
7 | DR-18 treatment enhances lymphocyte effector function. 7. DR-18扩增瘤内干细胞样T细胞 近年的文献显示,持久的免疫治疗反应需要表达TCF1和PD-1的干细胞样(stem-like)CD8+ T细胞前体细胞群,这些干细胞样前体细胞分化为终末效应细胞,将失去TCF1的表达,获得TIM3,具有更大的效应功能,但其自我更新能力有限[...
Our study establishes IL-18 as a target of lipopolysaccharide-activated caspase-4/5. The finding is paradigm shifting in the understanding of noncanonical-inflammasome-mediated defences and also the function of IL-18 in immunity and disease. This is a preview of subscription content, access via ...
www.nature.com/scientificreports OPEN received: 16 May 2016 accepted: 15 November 2016 Published: 13 December 2016 Sexual dimorphic function of IL-17 in salivary gland dysfunction of the C57BL/6.NOD-Aec1Aec2 model of Sjögren's syndrome Alexandria Voigt1, Lida Esfandiary1, Arun Wan...
总的来说,嗜酸性粒细胞是2型细胞因子(IL-4、IL-5和IL-13)的下游效应细胞,阻断2型细胞因子除了能够影响嗜酸性粒细胞的成熟和募集,还能够发挥更全面的抗炎作用以减轻哮喘的肺部炎症和肺功能下降。上述研究结果表明,阻断IL-4和IL-13的共同受体IL-4Rα能够通过影响外周血嗜酸性粒细胞计数、气道炎症和气道重塑等多...
IL-1家族有抗炎和促炎细胞因子,根据共有受体或共受体结合分为三个亚家族:IL-1、IL-18和IL-36。 IL-1亚家族包含:IL-1α,IL-1β,IL-33,结合共受体IL-1R3 IL-18亚家族包含:IL-18,IL-37结合共受体IL-1R5(也称之为:IL-18Rα) IL-36亚家族包含:IL-36α, IL-36β, IL-36γ,IL-36Ra 和 IL-...
T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to . To study the function of interleukin (IL)-4 receptor () on Th cells in , we infected specifically lacking α on (+) T cells (()α(-/) ) and α(-/) controls. ()α(-/) ...
18. However, we found no significant change in IL-18 mRNA stability when YBX1was knocked down (Fig.S6). Therefore, YBX1 might function as a transcription factor to regulate IL-18 transcription. Indeed, nuclear localized YBX1 could function as a transcription factor. From the JASPAR database...
More recently, the mechanisms by which IL-2 regulates CD4+ T cell differentiation and function have been elucidated. IL-2 also regulates the effector and memory responses of CD8+ T cells, and the loss of IL-2 or responsiveness to IL-2 at least in part explains the exhausted phenotype that...