IL-18 function is neutralized in IL-18 binding protein transgenic (IL-18BP Tg) mice. First we determined whether IL-18BP Tg mice are protected against ischemic acute kidney injury (AKI). Ischemic AKI was induced by bilateral renal pedicle clamping. IL-18BP Tg mice were functionall...
[1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol.[2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化...
ARTICLES nature publishing group Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3 þ Treg cell function in the intestine OJ Harrison1, N Srinivasan1, J Pott1, C Schiering2, T Krausgruber2, NE Ilott2 and KJ Maloy1 Elevated levels of interleukin-18 (IL-18) are found...
摘要 Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an inna...
[1]Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol. [2]李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化为...
Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide. Viral infection has been implicated as a triggering event that may initiate β-cell damage during the development of autoimmune diabetes. In this study, th... MR Heitmeier...
5. Carroll, R.G., et al., Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells. PLoS One, 2008. 3(9): p. e3289. 6. Uchida, T., et al., IL-18 time-dependently modulates Th1/Th2 cytokine production by ligand-activated ...
The finding is paradigm shifting in the understanding of noncanonical-inflammasome-mediated defences and also the function of IL-18 in immunity and disease. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals ...
[1] Chiossone, Laura et al. “Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.” Blood vol. [2] 李焱,叶敬伟,郭晓玲.IL-12、IL-15对急性髓系白血病患者骨髓来源CD34+白血病细胞转化...
Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities. Keywords: IL-18; psoriasis; atopic dermatitis; ...