Here, we report an unusual nasopharyngeal B cell lymphoma with both CCND1 rearrangement and MALT1 amplification. The patient was a 60 year old gentleman admitted for further evaluation of "unspecified lymphoma". PET oncology study revealed intense FDG avidity in the nasopharyngeal region, highly ...
To demonstrate and confirm the existence of cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) with IGH-CCND1 rearrangement and discuss the rationale of differentiating this entity from blastoid and pleomorphic variants of mantle cell lymphoma (MCL).Two cyclin D1-positive lymphomas with morph...
要包括11q13（CCND1）、4p16（FGFR3/MMSET）、16q23（CMAF）、6p21（CCND3）与20q11（MAFB）等不同亚型。本文就不同亚型IgH重排对MM的预后作一阐述，为MM的临床诊断，危险度分层及 治疗等提供帮助。【关键词】 多发性骨髓瘤；预后；IgH重排 The progress of IgH rearrangement in the prognosis of multiple...
IgH/CCND1基因的检测及其在MCL中意义的研究 姓名:*** 申请学位级别:硕士 专业:病理学与病理生理学 指导教师:** 20080510 硕士学位论文 IgH/CCND 1基因的检测及其在MCL中 意义的研究 硕士研究生:褚红娟 指导教师:**教授 摘要 研究背景和目的 淋巴瘤尤其是非霍奇金淋巴瘤(non-Hodgldn’slymphoma,NHL)是一类组 ...
Our current Multiple Myeloma panel (MMP) is designed as a reflex test, where positive IGH break-apart (IGH-BAP) and negative t(11;14)/IGH-CCND1 fusion patterns direct subsequent testing for t(4;14)/IGH-FGFR3 and t(14;16)/IGH-MAF fusions. Included in the first tier panel are probes...
g. in t(11;14)/CCND1-IGH -positive mantle cell lymphoma, occur predominantly near CpG dinucleotides, and to a lesser extent near the (A/T)GC(A/T) consensus motif (Greisman et al., 2012). Chromosomal breaks at a germinal center B-cell stage, e.g. with t(8;14)/MYC-IGH, were...
5 例IGH/CCND1 阳性,无IGH/MAF 阳性.结论:FISH 技术在MM 遗传学检测方面优于核型分析技术,IGH 重排阳性患者有必要进行IGH 重排亚型检测.%Objective To investigate the molecular cytogenetic abnormalties including 1q21 amplification, 13ql4 deletion, p53 deletion, IGH rearrangement in multiple myeloma (MM) ...
The t(11;14)(q13;q32) involving 1GH and CCND1 and Peter,M.,Lee,... - 《Journal of the Association of Genetic Technologists》 被引量: 0发表: 2016年 Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with transloc...
threeweredetectedtohaveIGH/FGFR3translocation,5weredetectedtohaveIGH/CCND1translocation,noneIGH/MAFtranslocationwereobserved.ConclusionFISHissuperiorthankarotypeinMMcytogeneticdetection,IGHrearranmentsubtypediscriminationisessentialforIGHrearrangementpositivepatients.【Keywords】Multiplemyeloma;InterphaseFISH;Molecular...
Cyclin D1-positive diffuse large B- cell lymphoma with IGH-CCND1 translocation and BCL6 rearrange- ment: a report of two cases. Am J Clin Pathol 2015;143:288-99.Cyclin D1-positive diffuse large B-cell lymphoma with IGH-CCND1 translocation and BCL6 rearrangement:a report of two cases. ...