Molecular studies revealed immunoglobulin heavy chain (IGH) gene rearrangement, while no T-cell receptor gene rearrangement was detected. The positron emission tomography scan showed that the lymphoma affected bilateral adrenal glands, pelvic cavity, peritoneal cavity, small intestine, skin, and subcutis...
上海玉博生物科技有限公司主要致力于“invivoscribe代理商之产品1-101-0030-11010030|IGH GENE REARRANGEMENT ASSAY MEGAKIT - GEL DETECTION 1-101-0030”的生产销售。多年的“invivoscribe代理商之产品1-101-0030-11010030|IGH GENE REARRANGEMENT ASSAY MEGAKIT - GEL DE
The objective of our study was to determine whether CSF testing for clonal IgH gene rearrangement correlates with the activity and response to therapy in patients with isolated CNS lymphoma. In addition, we compared the rate of concordant and discordant results between PCR analysis and conventional ...
Autoimmune phenomena associated with IGHV4-34 gene were represented by cold agglutinin haemolytic anemia in 2 pts with IgM-RD and 1 with WM. Conclusions: the identification of a monoclonal IGHV-D-J rearrangement seems more feasible in WM as compared to MGUS and IgM-RD. In all three groups,...
Ign generearrangement single cell micromanipulation indirectinsituPCR -5一 壁主堑垄兰兰些堡圣—— cHL H/RS及背景淋巴细胞BSAP表达与IgH基固重排检测 日U 吾 1832年,Thomas Hodgkin根据临床观察和尸检,首次描述了被后 人称为霍奇金氏病(Hodgkin’SDisease,HD)的疾病‘”.新近WHO命名 ...
et al. Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies. J. Immunol. 191, 2393–2402 (2013). Article CAS Google Scholar Lin, S. G. et al. Highly sensitive and unbiased approach for elucidating antibody repertoires. Proc. ...
IgHgenerearrangement Canmake help to distinguishbenign tissues from malignantlymphomas,andmaygive somecluetothe origin ofdifferent types of lymphoma.The chromosome t(11;14)(q13;q32)translocation is themost specific cytogenetic alterationofMCL,whichresultsin ...
The recombination frequency of each VK gene is indicated as a percentage of all VK-JK rearrangement events and is shown as a mean value with SEM based on six independent VDJ-seq experiments for each pro-B cell type. The different VK genes (horizontal axis) are aligned according to their ...
Gene rearrangementstudies forTCRandIGH@ are negative. • EBVis negative. • X-chromosome inactivation studies may suggestclonalityin female patients. • A restricted pattern of killer immunoglobulin-likereceptor expressionhas been used as a maker for clonality in this disorder. ...
each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturati...