IgH gene rearrangementWe report stability of a clonal immunoglobulin heavy chain (IgH) gene rearrangement in a case of childhood acute lymphoblastic leukaemia (ALL) relapsing 17 years after completion of first-line therapy. Clonal stability was shown by polymerase chain reaction amplification of the ...
In the other patient, however, the sequence of the rearrangement present 5 months prior to L-BT was unrelated to the rearrangements at the time of L-BT indicating a pattern of clonal succession. We conclude that: (1) IgH gene rearrangements are detectable in the majority of patients with L...
(DLBCL) of the skin; the clonal relationship of the DLBCL with the preexisting MZ-like lymphocytosis could not be investigated due to the inability to obtain by PCR the clonotypic IGHV-IGHD-IGHJ gene rearrangement of the DLBCL, likely because of technical reasons (formalin-fixed, paraffin-...
Cluster 10 is the cluster with the unique VDJ rearrangement of IGH that is shown in a and the large number of mutations attributed to signature 9. Clearly, samples from clusters 2, 11, 55 and so on have VAFs which, when combined with cluster 10, sum to >0.5. Therefore, they must be...
62,63 The possible occurrence of VH gene replacement has been suggested by analysis of the VH repertoire of human B-lineage ALL55,64 and in a transgenic mouse carrying a VDJH rearrangement targeted to the endogenous IgH locus.65 Confirmation of ongoing VH gene replacement as a mechanism to ...
The ASXL1 gene was an exception, which is affected more frequently in myeloid leukemias [13]. NGS confirmed the presence of the IGH::BCL2 fusion, CK, and detected two clonal IG light chain rearrangements. The variant t(8;22) was not detected, possibly due to the lower sensitivity of ...
(IGH), and oneBCL2-IGH. The PCR products of Ig/TCR genes can be analyzed for clonality assessment by heteroduplex analysis or GeneScanning. The detection rate of clonal rearrangements using the BIOMED-2 primer sets is unprecedentedly high. This is mainly based on the complementarity of the ...
Almost four months after HCT, she developed progressive pancytopenia, biclonal gammopathy, and IGH gene rearrangement. Donor-Derived Smoldering Multiple Myeloma following a Hematopoietic Cell Transplantation for AML Possible explanations may include a synchronous biclonal origin (collision tumor) [10] and ...
2) IgH gene clonality IgH基因克隆性重排 1. The application of detection of rearrangement ofIgH gene clonalityin B cell lymphoma; IgH基因克隆性重排检测在B细胞淋巴瘤诊断中的应用 3) rearrangements 克隆性重排 例句>> 4) Monoclonal rearrangement ...
In the present study we analyzed the IgH gene rearrangement status in 18 cases with relapsing pre-B ALL using variable heavy chain (VH) gene family specific polymerase chain reaction (PCR) amplification and single stranded conformation polymorphism (SSCP) analysis. Clonal IgH rearrangements were ...