NCG mice lacking functional murine T, B, NK cells as well as decreasing functional macrophage and dendritic cells could be used as recipients of human peripheral blood mononuclear cells (huPBMC) for the studies of human GVHD. In this study, huPBMC-NCG mice were developed by the engraftment ...
Methods: Female huPBMC-NCG (human peripheral blood monocyte cells-injected NCG) mice were implanted subcutaneously with 5 脳 106 A375 human melanoma cells. Tumors were grown for 21 days (~60 mm3), then mice were imaged with FDG-PET and 64Cu-DOTHA2-FAPI-04-PET within a 3-day interval ...