HIP1 is a 116 kDa cytosolic protein that was originally identified to interact with huntingtin, the protein whose gene is mutated in Huntington disease. HIP1 and its only known mammalian relative, HIP1-related ( HIP1r ), contain clathrin -binding domains and carboxyl terminal actin -binding ...
The huntington interacting protein (HIP1) is enriched in membrane-containing cell fractions and has been implicated in vesicle trafficking. It is a multidomain protein containing an N-terminal ENTH domain, a central coiled-coil forming region and a C-terminal actin-binding ...
上海玉博生物科技有限公司 主要致力于“PIERCEMA116747Anti-Huntingtin Interacting Protein 1 Monoclonal Antibody100 100 µl”的生产销售。多年的“PIERCEMA116747Anti-Huntingtin Interacting Protein 1 Monoclonal Antibody100 100 µl”生产与销售的经验,与
Of the htt-interacting proteins identified, huntingtin-associated protein-1 and huntingtin-interacting protein-1 have been well characterized. Both are involved in intracellular trafficking [17,18], strongly suggesting that htt functions as a trafficking protein. Consistent with the accumulation ...
Huntingtin相互作用蛋白(Huntingtininteractingprotein,HIP)是一类与Huntingtin蛋白相互作用的蛋白。Huntingtin蛋白的异常表达可引起亨廷顿氏病(Huntington’sdisease,HD)。Huntingtin蛋白含有一多聚谷氨酰氨区域,一富集脯氨酸区域,3-4个HEAT重复(Cell,81,811-823,1995),Huntingtin只通过其N端富集脯氨酸片段与各类蛋白(HYPs,...
The hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. A number of neurotransmitters in the hypothalamus, including γ-aminobutyric acid (GABA), also have key roles in feeding. Huntingtin-associated protein 1 (Hap1) is expressed more abundantly ...
An Actin-Binding Protein of the Sla2\\/Huntingtin Interacting Protein 1 Family Is a Novel Component of Clathrin-Coated Pits and Vesicles Examines the role of an actin-binding protein of the Sla2/huntingtin interacting protein 1 as a component of clathrin-coated pits and vesicles. Link betwe....
The best-described example is the case of huntingtin-associated protein 1 (HAP1), which is discussed later. Huntingtin also interacts with huntingtin-interacting protein 1 (HIP1), which binds to the clathrin light chain and regulates clathrin assembly, linking huntingtin to the control of ...
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In an attempt to elucidate the molecular mechanism of Apoptin-induced apoptosis, we identified human Hippi, the protein interactor and apoptosis co-mediator of Huntingtin interacting protein 1, as one of the Apoptin-associated proteins by yeast two-hybrid screen. We also demonstrated that Hippi ...