Huntingtin-interacting protein 1-related proteinHip (disambiguation)
Of the htt-interacting proteins identified, huntingtin-associated protein-1 and huntingtin-interacting protein-1 have been well characterized. Both are involved in intracellular trafficking [17,18], strongly suggesting that htt functions as a trafficking protein. Consistent with the accumulation ...
The hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. A number of neurotransmitters in the hypothalamus, including γ-aminobutyric acid (GABA), also have key roles in feeding. Huntingtin-associated protein 1 (Hap1) is expressed more abundantly ...
Huntingtin also interacts with huntingtin-interacting protein 1 (HIP1), which binds to the clathrin light chain and regulates clathrin assembly, linking huntingtin to the control of endocytosis. A role of huntingtin in the control of endocytosis is further supported by the observation that huntingtin...
Huntingtin-interacting protein 1 related (Hip1R) is a novel component of clathrin-coated pits and vesicles and is a mammalian homologue of Sla2p, an actin-... sa E.Y. Engqvist-Goldstein,RA Warren,MM Kessels,... - 《Journal of Cell Biology》 被引量: 439发表: 2001年 An actin-binding ...
The development of the disease phenotype is related to the aggregation of the HD gene products in the cytoplasm.Cytogenetics & Cell GeneticsZimdahl, H.Gsele, C.Lütjens, G.Grützner, F.Kreitler, T.Voss, K.Wanker, E.Knoblauch, M.
Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fragments by using
Mislocalization and aggregation of the huntingtin protein are related to Huntington's disease. Its first exon-more specifically the first 17 amino acids (Htt17)-is crucial for the physiological and pathological functions of huntingtin. It regulates huntingtin's activity through posttranslational ...
Because normal HTT pro- tein localizes to plasma and intracel- lular membranes, and has been shown to be palmitoylated (by huntingtin interacting protein, HIP14), the team considered that palmitoylation might also regulate HTT's normal function. And it does. The team first identified which ...
Heat shock protein A12B (HSPA12B) is the newest member of a recently defined subfamily of proteins distantly related to the 70-kDa family of heat shock pro... L Kang,G Zhang,Y Yan,... - 《Neurochemical Research》 被引量: 34发表: 2013年 Psychotropics regulate Skp1a, Aldh1a1, and Hspa...