1. Objective This project aims to elucidate whether Huntingtin associated protein 1(HAP1) plays a role in the endocytosis and retrograde transport of BDNF and its receptors,which may offer a way to investigate the molecular biology mechanism of Huntington disease. 目的拟探讨亨廷顿蛋白相关蛋白1(HAP...
aLive album <<1 2个世纪Concert>>活册页[translate] aDESIGNATION: 正在翻译,请等待...[translate] aHuntingtin-Associated Protein 1 is essential for postnatal growth by regulating neurogenesis Huntingtin伴生的蛋白质1为出生后成长是根本的通过调控neurogenesis[translate]...
Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport...
1. The expression of motility-related-protein-1(MRP-1),a cell- motility- inhibiting protein was reported to be down-regulated and gave rise to the malignant phenotype associated with invasion and metastasis. 背景与目的肿瘤细胞发生浸润转移的首要基础是细胞移动性增强,此过程受到极其复杂的多基因调控...
Using the yeast two-hybrid system, we isolated a rat cDNA encoding part of a protein that interacts with HAP1, and we confirmed the specificity of this interaction using an in vitro protein-binding assay. We called the protein Duo because it is closely related to the human protein Trio but...
The hypothalamus responds to circulating leptin and insulin in the control of food intake and body weight. A number of neurotransmitters in the hypothalamus, including γ-aminobutyric acid (GABA), also have key roles in feeding. Huntingtin-associated pro
1998. The expression of Huntingtin-associated protein (HAP1) mRNA in developing, adult and ageing rat CNS: implications for Huntington's disease neuropathology. Eur. J. Neurosci. 10:1835-45Page,KJ,Potter,L,Aronni,S,Everitt,BJ,Dunnett,SB.The expression of Huntingtin-associated protein (HAP1) ...
Huntingtin-interacting protein 1 (HIP1) interacts with huntingtin, the protein whose gene is mutated in Huntington's disease. In addition, a fusion between HIP1 and platelet-derived growth factor beta receptor causes chronic myelomonocytic leukemia. The HIP1 proteins, including HIP1 and HIP1-relate...
Htt-associated protein-1 (HAP1) was the first identified Htt-binding p... TS Tang,H Tu,PC Orban,... - 《European Journal of Neuroscience》 被引量: 30发表: 2015年 Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate ...
huntingtin interacts with many proteins that are implicated inintracellular trafficking. The best-described example is the case of huntingtin-associatedprotein 1(HAP1), which is discussed later. Huntingtin also interacts with huntingtin-interacting protein 1 (HIP1), which binds to theclathrinlight chain...