Huntingtin Protein, Kinases And The Search For The Origin Of Huntington DiseaseNews Staff
Antibody-beads conjugates were prepared by adding 2 μg to 500 μl of IP Lysis Buffer in a microcentrifuge tube, together with with 30 μl of Dynabeads protein A- (for rabbit antibodies) or protein G- (for mouse and rat antibodies) beads. ...
Anti-Huntingtin Protein Antibody, a.a. 181-810, clone 1HU-4C8 ascites fluid, clone 1HU-4C8, Chemicon®; Synonyms: Huntingtin, Huntington′s Disease Protein, HD Protein; find Sigma-Aldrich-MAB2166 MSDS, related peer-reviewed papers, technical documents,
The mutation in Huntington's disease is a polyglutamine expansion near the N-terminus of huntingtin. Huntingtin expressed in immortalized neurons is cleaved near the N-terminus to form N-terminal polypeptides known as cleavage products A and B (cpA and cpB). CpA and cpB with polyglutamine expansi...
Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fragments by using conventional molecular cloning techniqu...
Huntington's disease (HD) is caused by a CAG repeaBo Wang a b cLi Zeng a dSean A. Merillat aSvetlana Fischer aJoseph Ochaba e fLeslie M. Thompson e fSami J. Barmada aKenneth M. Scaglione gHenry L. Paulson a bNeurobiology of Disease...
Li SH, Li XJ (2004) Huntingtin-protein interactions and the pathogenesis of Huntington’s disease. Trends Genet 20:146–154Li, S.H., and X.J. Li. 2004. Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet. 20:146-154....
Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive personality changes, movement disorder, and dementia and can develop in children and adults. The huntingtin protein is required ...
Sari Y: Huntington's Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy Int J Biomed Sci. 2011 7/2:89-100Y. Sari, "Huntington's disease: from mutant huntingtin pro- tein to neurotrophic factor therapy," International Journal of Biomedical Sciences, vol. 7, no. 2, pp. ...
Levels of mHTT, as well as N-, and C-terminal and mid-region huntingtin were measured in the PBMCs using ELISA-based Meso Scale Discovery (MSD) electrochemiluminescence immunoassay platforms, and we evaluated the relationship between different HTT species, disease stage, and brain atrophy on ...