A humanized monoclonal antibody, comprising the complementarity-determining regions of a parental murine Class III, anti-CEA monoclonal antibody engrafted to the framework regions of a heterologous antibody, wherein the humanized monoclonal antibody retains the binding specificity of, but is less ...
After evaluating the efficacy of its chimeric version and humanized variants, we successfully generated a humanized FABP4 monoclonal antibody (mAb), which offers potential for treating breast cancer in the clinic. Materials and methods Generation of mouse monoclonal antibody FABP4 mAbs were generated ...
6. Reff ME, Carner K, Chambers KS, Chinn PC, Leonard JE, Raab R, Newman RA, Hanna N, Anderson DR. Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood. 1994 Jan 15;83(2):435-45. PMID: 7506951. 7. Maloney DG, Liles TM, Czerwinski DK, ...
The finding that unmutated IGHV1-69 encoded BCRs are frequently expressed on B-CLL cells provides an opportunity for anti-idiotype monoclonal antibody immunotherapy. In this study, we first showed that MuG6 can deplete B cells encoding IGHV1-69 BCRs using a novel humanized GTL mouse model. ...
Humanized Monoclonal Antibodydoi:10.1007/978-3-642-16483-5_6844A type of monoclonal antibodymade in the laboratory by combining a human antibody with a small part of a mouse or rat monoclonal antibody. The mouse or rat part of the antibody binds to the target......
5.Non-clinical Pharmacokinetic and Pharmacodynamic Study of Humanized Anti-CD20 Monoclonal Antibody;重组抗CD20人源化单克隆抗体的非临床药代动力学与药效动力学研究 6.The Initial Research of the Preparation of Humanized Mouse Anti-human cTnI Antibody;鼠源性抗人心肌肌钙蛋白I单克隆抗体人源化改造的初步研究...
Certolizumab pegol is a humanized antibody Fab fragment, designed by engrafting the mouse complementarity determining region (CDR) into a human IgG4 k Fab framework, and it has a polyethylene glycol (PEG) molecule attached that prolongs the half-life in the circulation; the construct is expressed...
Among animal species, the laboratory mouse has been instrumental in modeling human biology and disease. It is well-documented that the mouse is a powerful tool in the understanding of human biological pathways such as hematopoiesis as well as providing insights into human diseases, suc...
CDR-GRAFTED TYPE III ANTI-CEA HUMANIZED MOUSE MONOCLONAL ANTIBODY PROBLEM TO BE SOLVED: To provide an immunological reagent having the anti-CEA-binding properties of mouse Class III and anti-CEA mAb(monoclonal antibody) and human mAb's immunogenicity in human patients. SOLUTION: A humanized monoclo...
Each animal was euthanized when its tumor reached the volume endpoint. The time to endpoint (TTE) for each mouse was calculated with the following equation: (log10(endpoint volume)—b)/m, where b is the intercept, m is the slope of the line obtained by linear regression of log-transformed...