Chitinase-3 like-1 proteinFully human monoclonal antibodyPreclinical cancer modelsFibrosisAngiogenesisConsidering the limited efficacy of current therapies in lung, colorectal, and pancreatic cancers, innovative combination treatments with diverse mechanisms of action are needed to improve patients' outcomes. ...
YUMAB, a global provider of fully human monoclonal antibodies, offers ultra-fast discovery and efficient lead development. The company is looking to expand its network of collaborators and clients through flexible licensing options for diagnostics and th
“The fully human monoclonal antibodies developed using our RenMabTM platform exhibit exceptional binding and internalization capabilities, along with excellent developability. By utilizing Synaffix’s platform and combining it with SOTIO’s extensive experienc...
Figures & data Figure 1.Isolation of GP-specific antibodies from immunized transgenic mice. (A) Immunization strategy of antibody-humanized transgenic mice, CAMouse. Each mouse was immunized with five injections of antigens comprised of EBOV GPΔmuc and rVSV-EBOV GP at 2-week intervals starting...
Bevacizumab (Avastin, Roche), a humanized monoclonal immunoglobulin G1 antibody targeting circulating VEGF, has been shown to improve clinical outcomes in combination with chemotherapy in various cancer types, such as colorectal, lung and ovarian cancers [4–9]. Small molecular inhibitors, like ...
reported a humanized anti-ROR1 monoclonal antibody cirmtuzumab repressed expression of genes associated with breast cancer stemness and reduced activation of Rho-GTPases, Hippo-YAP/TAZ, or BMI1 [41]. Liu et al. constructed a novel ROR1 inhibitor ARI-1 to suppress the development of Non-...
Hajjar G, Sharkey RM, Burton J, Zhang CH, Yeldell D, Matthies A, Alavi A, Losman MJ, Brenner A, Goldenberg DM: Phase I radioimmunotherapy trial with iodine-131--labeled humanized MN-14 anti-carcinoembryonic antigen monoclonal antibody in patients with metastatic gastrointestinal and colorectal ca...
Monoclonal antibodies include humanized monoclonal antibodies. A“chimeric antibody” has framework residues from one species, such as human, and CDRs (which generally confer antigen binding) from another species, such as a murine antibody that specifically binds HMW-MAA. A“human” antibody (also ...
“Humanized Anti-vascular Endothelial Growth Factor Monoclonal Antibody, Preparation Method and Pharmaceutical Composition Thereof” filed on Mar. 20, 2002, the antibody obtained according to the present invention has higher antibody affinity and stronger inhibition effect on tumor cell proliferation; and ...
Preferably, the constant region of the neutralizing monoclonal antibody of this invention is the one from any of human IgG1, IgG2, IgG3 or IgG4. The anti-tetanus toxin antibody or its antigen binding fragment of this invention is preferable humanized antibody, comprising (not limited to) singl...