Humanization of monoclonal antibodies. In: Rozenberg M, Gordon P, Moore P, editors. Handbook of Experimental Pharmacology, vol. 113. Berlin: Springer-Verlag, 1994:105- 34.G. Mark et al, " Humanization of Monoclonal Antibodies ", Chapter 4, The Handbook of Experimental Pharmacology, vol. 113...
Summary Humanization of monoclonal antibodies (mAbs) from animal sources comprises strategies for reducing their immunogenicity and for improving their activation of the human immune system. There are now many humanized mAbs in late phase clinical trials and several have been given approval to be used...
Sandhu, " A rapid procedure for the humanization of monoclonal antibodies ", Gene, 150:409-410 (1994).Sandhu, J. S.: A rapid procedure for the humanization of monoclonal antibodies. (1994) Gene 150, 409-410.Sandhu , A rapid procedure for the humanization of monoclonal antibodies, Gene (...
Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known antibody structures has been used to determine the relative solvent accessibility distributions of amino acid residues in murine and human...
The meaning of HUMANIZE is to represent (something) as human : to attribute human qualities to (something). How to use humanize in a sentence.
Pendley C, Schantz A, Wagner C (2003) Immunogenicity of therapeutic monoclonal antibodies. Curr Opin Mol Ther 5:172–179 CAS PubMed Google Scholar Jespers LS, Roberts A, Mahler SM, Winter G, Hoogenboom HR (1994) Guiding the selection of human antibodies from phage display repertoires to a...
In: Ziqing An (ed) Therapeutic monoclonal antibodies: from bench to clinic. John Wiley & Sons, Inc., Hoboken, pp 302–327Almagro, J. C. and Strohl, W. R. (2009). Antibody engineering: Humanization, affinity maturation, and selection techniques. In Z. An (ed.), Therapeutic monoclonal ...
Antibody framework residues affecting the conformation of the hypervariable loops Rodent monoclonal antibodies have been "humanized" or "reshaped" for therapy by transplanting the antigen-binding loops from their variable domains onto th... Jefferson,Foote,and,... - 《Journal of Molecular Biology》 ...
Establishment of humanized anti-interleukin-5 receptor alpha chain monoclonal antibodies having a potent neutralizing activity We also describe the process for humanization of the mouse Mab towards development of a therapeutic MAb. The humanized version of the monoclonal antibody ... M Koike,K Nakamura...
a.To modify (a nonhuman compound, cell, organ, or organism) such that some of its components are replaced with human forms of those components, usually by means of genetic engineering. b.To replace most of the variable region of (a monoclonal antibody from a nonhuman source) with a human...