i-Bodies, human single domain antibodies that antagonize chemokine receptor CXCR4. J Biol Chem. 2016;291:12641-57.Griffiths, K.; Dolezal, O.; Cao, B.; Nilsson, S.K.; See, H.B.; Pfleger, K.D.G.; Roche, M.; Gorry, P.R.; Pow, A.; Viduka, K.; et al. I-bodies, human...
To determine if the increased cross-reactivity to other α-neurotoxins translated into cross-neutralization, a single concentration antibody screen was set up using the Qube 384 system. Here, the three antibodies (368_01_C05, 2551_01_A12, and 2554_01_D11) were tested against α-cobratoxin f...
The single-domain Ab of camelidae is fragmentary and a therapeutic Ab. Due to the small size (~ 15 kDa) and the fast metabolism (~ 30 min) in the organisms19,20,21, appropriate modifications are essential to improve the pharmacokinetic and pharmacodynamic performances of single domain Abs...
文献阅读——Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain ... goblin7 20508 目录 收起 1. Author 2. Background 2.1丙氨酸扫描突变 3. Methods 4. Results 5. Discussion 1. Author James E. Crowe, Jr. James E. Crowe, Jr.实验室研究重点是人类B细胞...
Human antibodies specific for digoxigenin, estradiol, testosterone and progesterone have been isolated from a small combinatorial IgM repertoire (4×107) of single chain antibodies (scFv). The affinities of both the anti-estradiol and anti-progesterone scFv were approximately 108 M−1. Naive IgM ge...
They can also provide greater sensitivity through signal amplification as multiple secondary antibodies can bind to a single primary antibody. Most commonly, secondary antibodies are generated by immunizing the host animal with a pooled population of immunoglobulins from the target species and can be ...
They can also provide greater sensitivity through signal amplification as multiple secondary antibodies can bind to a single primary antibody. Most commonly, secondary antibodies are generated by immunizing the host animal with a pooled population of immunoglobulins from the target species and can be ...
the sequence IIN to LLN. Binding of mAbs was quantified by ConA ELISA as described above. Mutations that reduced binding to 10% or less of control or 11–24% of control are highlighted. (d) Binding of mAbs to GP1 constructs in which the indicated single amino acids in GP1 were mutated ...
combinations. Furthermore, we estimated the broad-spectrum activity of VV116 and its enhanced effect when combined with nirmatrelvir in mouse models. This study is expected to provide an overall insight into the anti-HCoV potential of the nucleotide analog VV116 in both single and combination ...
Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients’ B cells Cell, 182 (2020), pp. 73-84.e16 View PDFView articleView in ScopusGoogle Scholar Case et al., 2020a J.B. Case, A.L. Bailey, A.S. Kim, R.E. Chen...