The inventive compositions can be used in methods of inducing antibody dependent cellular cytotoxicity (ADCC) in a host (e.g., to inhibit cancer or an infectious disease, such as a viral infection).DIMITROV, DIMITER S.CHEN, WEIZAOLI, WEI...
文献阅读——Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain ... goblin7 20508 目录 收起 1. Author 2. Background 2.1丙氨酸扫描突变 3. Methods 4. Results 5. Discussion 1. Author James E. Crowe, Jr. James E. Crowe, Jr.实验室研究重点是人类B细胞...
To determine if the increased cross-reactivity to other α-neurotoxins translated into cross-neutralization, a single concentration antibody screen was set up using the Qube 384 system. Here, the three antibodies (368_01_C05, 2551_01_A12, and 2554_01_D11) were tested against α-cobratoxin f...
The single-domain Ab of camelidae is fragmentary and a therapeutic Ab. Due to the small size (~ 15 kDa) and the fast metabolism (~ 30 min) in the organisms19,20,21, appropriate modifications are essential to improve the pharmacokinetic and pharmacodynamic performances of single domain Abs...
They can also provide greater sensitivity through signal amplification as multiple secondary antibodies can bind to a single primary antibody. Most commonly, secondary antibodies are generated by immunizing the host animal with a pooled population of immunoglobulins from the target species and can be ...
AntibodySystem由具有30多年蛋白抗体开发经验的 创立于法国,专注于生命科学和生物制药领域研究,总部位于法国斯特拉斯堡市。AntibodySystem自主开发了高效、高产的真核重组表达系统,利用该系统生产了高质量的重组蛋白、抗体产品。目前产品包括药物靶点蛋白以及对照抗体药物、Invivo功能性抗体、SAA系列流式抗体、PEG抗体、磷酸化...
T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/de...
The C-terminal domain of GDF-15 contains seven characteristic conserved cysteine residues necessary for the formation of the cysteine knot and the single inter-chain disulfide bond (4, 5). Biologically active GDF-15 is a disulfide-linked homodimer of the mature protein. GDF‑15 has been shown...
Kong, R. et al. Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies.J. Virol.86, 12115–12128 (2012). ArticleCASGoogle Scholar Liao, H. X. et al. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.J. Virol...
Binding affinity of mbk6 and mbk11 as measured by SPR and ELISA. Panel a and b show the SPR sensorgrams of mbk6 and mbk11, respectively. SPR experiments were performed on a single cycle mode. CD16A was coated onto a CM5 chips and different concentrations of BiKEs was injected. The kine...