The Single Domain Antibody Database, or sdAb-DB, ( www.sdab-db.ca ) is the first freely available repository for single domain antibodies and related classes of proteins. Due to their small size, modular structure, and ease of expression, single domain antibodies (sdAb) have a wide range ...
The cell segmentation labeling can be read by a fluorophore-conjugated readout probe (red); AB1, antibody 1; AB2, antibody 2. e, Cell segmentation staining of a 10-µm thick transverse section of an E8.5 mouse embryo using the strategy introduced in d. Cell segmentation signal was used ...
Using a single-domain antibody (sdAb), NM-01, against PD-L1, radiolabeled site-specifically with technetium-99m (99mTc) for SPECT imaging, these researchers evaluated the safety, radiation dosimetry and imaging characteristics of this radio-pharmaceutical and correlated tumor uptake with PD-L1 immuno...
Our study revealed that there is an overlap between the genes that are differentially expressed in psoriasis patients receiving three anti-IL17A monoclonal antibody drugs and the genes that are differentially expressed in lesion versus non-lesion samples in these patients. Further analysis using single-...
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(somatomedin B and thrombospondin type 1 domain containing),CXCL14(C-X-C motif chemokine ligand 14) andSFRP5(secreted frizzled related protein 5). Lastly, module F may have been associated with technical variables, with more commitment seen in cells when compared with nuclei (Extended Data Fig...
Membranes were blocked with 5% (w/v) skimmed milk powder and immunoblotted with suitably diluted primary antibody AKR1C4 (Cat No: A7430, ABclonal, China) at a dilution of 1:200 followed by secondary antibodies (goat anti-rabbit IgG; Cat No: SE134, Solarbio, China) at dilution of 1:...
To test this hypothesis, an FST neutralizing antibody (anti-FST) or recombinant FST was injected onto the hypothalamus of HH5/6 embryos in vivo, which were then developed to HH14 (Figures 7C–7F). Anti-FST increased the NKX2-1/SHH-positive hypothalamic domain relative to controls and ...
To enable enrichment of infrequent cell types, AT2 cells were partially depleted using the anti-MHC II antibody74 or AT2 and ciliated cells were partially depleted using the anti-CD24 antibody. With partial depletion, only approximately 10% of AT2 and ciliated cells were kept, but GFP+ AT2 ...
Second, SCALEX includes a Domain-Specific Batch Normalization (DSBN)31 layer using multi-branch Batch Normalization32 in its decoder to support incorporation of batch-specific variations during single-cell data reconstruction. Third, the SCALEX encoder employs a mini-batch strategy that samples data ...