这一版的《Single-Domain Antibodies: Methods and Protocols》,是2012年同名书籍的更新,分为五个部分:第一部分对sdAbs进行概述;第二部分对从几个平台分离sdAbb所使用的技术进行介绍;第三部分为在生物体中制备sdAbs和相关分子的技术介绍;第...
We specialise in the discovery and engineering of VHHs - small-format, single-domain antibodies. Explore the world's largest VHH libraries.
Here, we characterized a collection of single-domain antibodies (VHHs) whose epitopes overlap with the P-stalk binding pocket on RTA. The crystal structures of three such VHHs (V9E1, V9F9, and V9B2) in complex with RTA revealed not only occlusion of the ribosomal P-stalk binding pocket ...
bodies can maintain their biological activity under high pressure, strong acid, and strong base conditions. Although a VHH antibody lacks a light chain, it has a longer CDR3 and can bind tightly to antigens; therefore, the affinity of nanobodies is comparable to that of conventional antibodies...
Nevertheless, single-domain antibodies (VHHs), also known as nanobodies, present a promising alternative. VHHs possess unique characteristics over ADCs, including a smaller size, enhanced tissue penetration, and rapid clearance. Their stability, solubility, and manufacturability surpass those of ...
Generation of human single-chain variable fragment antibodies specific to dengue virus non-structural protein 1 that interfere with the virus infectious cycle 热度: Selection and expression of recombinant single domain antibodies from a hyper-immunized library against the hapten azoxystrobin 热度: ...
Here, we describe the selection and characterization of single-domain antibodies against the LUBAC subunit HOIP, which provide access to stable and reproducible crystals of the HOIP RBR domain that can be used for soaking of small-molecule inhibitors. Considering the importance of LUBAC in the ...
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VHH single-domain antibodies have been demonstrated to neutralize diverse bacterial toxins both and , with protein properties such as small size and high stability that make them attractive therapeutic candidates. Recently, we reported on VHHs with activity against the protective antigen component of ...
(ADCs) have become one of the hotspots in the development of anticancer therapies. Although significant progress has been achieved, there remain challenges to overcome, including limited penetration into solid tumors and potential immunogenicity. Fully human single-domain antibodies (UdAbs), with their...