Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone development ... T Pillay,S Muyldermans - 《Annals of Laboratory Medicine》 被引量: 0发表: 2021年 Single-Domain Antibodies or Nanobodies: A Class of Ne...
Single- domain antibodies that compete with the natural ligand fibroblast growth factor block the internalization of the fibroblast growth factor receptor 1. Biochem. Biophys. Res. Commun. 408 (4), 692-696.Veggiani G, Ossolengo G, Aliprandi M, Cavallaro U, de Marco A. Single-domain ...
Generation of human single-chain variable fragment antibodies specific to dengue virus non-structural protein 1 that interfere with the virus infectious cycle 热度: Selection and expression of recombinant single domain antibodies from a hyper-immunized library against the hapten azoxystrobin 热度: ...
et al. Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response. Oncoimmunology 10, 1854529 (2020). Article PubMed PubMed Central Google Scholar Safran, H. et al. Phase 1/2 study of DF1001, a novel tri-specific, NK cell engager therapy targeting HER2, ...
et al. Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune response. Oncoimmunology 10, 1854529 (2020). Article PubMed PubMed Central Google Scholar Safran, H. et al. Phase 1/2 study of DF1001, a novel tri-specific, NK cell engager therapy targeting HER2, ...
Alzheimer’s disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Abeta pathological molecules. Sci Rep. 2016;6:28912. Kayed R, Lasagna-Reeves CA. Molecular mechanisms of amyloid oligomers toxicity. J Alzheimers Dis...
Here we examine the circulating B cell populations of ten human subjects and present what is, to our knowledge, the largest single collection of adaptive immune receptor sequences described to date, comprising almost 3 billion antibody heavy-chain sequences. This dataset enables genetic study of ...
The interactions of DGCG and chloroquine with the ACE2 metallopeptidase domain active site displays a single hydrogen bond with the residue of Thr445 for chloroquine. Nine hydrogen bond interactions for DGCG are found with Glu406, Phe274, His345, Tyr127, Asn149, Lys363, Asp367, and Asp368...
B4-Crry, a fusion protein consisting of a single-chain Ab derived from B4 mAb, linked to the complement inhibitor Crry, significantly protected against SCI. B4-Crry exhibited a dual function in that it inhibited both the binding of pathogenic IgM and blocked complement activation in the ...
Noroviruses have a single-stranded, positive sense RNA genome of ~ 7.4 to 7.7 kbases. The genome contains three open reading frames (ORFs), where ORF1 encodes the non-structural proteins, which include the protease and RNA dependent RNA polymerase (RdRp), ORF2 encodes the capsid protein...