The present invention relates to from single structure territory heavy chain antibody polypeptides derived at tumor necrosis factor-alpha.The invention still further relates to single domain antibody, these antibody are Camelidae VHHs.Also relate to the method for using described polypeptide.Also relate ...
The structure includes two constant regions (CH2 and CH3), a hinge region, and a variable heavy-chain domain (VHH). From this, a single-domain antibody containing only a VHH domain was obtained. The crystal structure of VHH antibody is an oval shape of 4 nm×2.5 nm×3 nm in size, ...
VHH) 基础上开发了一种仅由重链可变区构成的单域抗体(single domain antibody, sdAb),长4 nm,直径2.5 nm,分子量为12–15 kDa,是目前已知最小的活性抗原结合蛋白,仅为传统抗体大小的十分之一,也被称为纳米抗体(nanobody,Nb),其独特的结构和优越的特性使其成为多领域的研究热点。
The antibody is a single heavy chain single domain antibody (VHH) capable of specifically binding to CTLA-4. Also provided are a pharmaceutical composition comprising the CTLA-4 antibody, and a use of the antibody for preparing drugs.XU, Ting...
纳米抗体(nanobody, Nb),即重链抗体VHH(variable domain of heavy chain of heavy-chain antibody)——骆驼体内存在着天然缺失轻链的重链抗体(heavy-chain antibody, HCAb),克隆其可变区而得到的只由一个重链可变区组成的抗体,是目前可以得到的具有完整功能的稳定的可结合抗原的最小单位。
single-domain antibodyphage displayenzymatic activityantigenic siteAvian influenza A virus comprises sixteen hemagglutinin (HA) and nine neuraminidase (NA) subtypes (N1鈥揘9). To isolate llama single-domain antibody fragments (VHHs) against all N subtypes, four llamas were immunized with mixtures of ...
纳米抗体(nanobody, Nb),即重链抗体VHH(variable domain of heavy chain of heavy-chain antibody)——骆驼体内存在着天然缺失轻链的重链抗体(heavy-chain antibody, HCAb),克隆其可变区而得到的只由一个重链可变区组成的抗体,是目前可以得到的具有完整功能的稳定的可结合抗原的最小单位。
Antibody-mediated modulation of major histocompatibility complex (MHC) molecules, or MHC class I-like molecules, could constitute an effective immunotherapeutic approach. We describe how single-domain antibodies (VHH), specific for the human MHC class I-like molecule CD1d, can modulate the function of...
纳米抗体(nanobody, Nb),即重链抗体VHH(variable domain of heavy chain of heavy-chain antibody)——骆驼体内存在着天然缺失轻链的重链抗体(heavy-chain antibody, HCAb),克隆其可变区而得到的只由一个重链可变区组成的抗体,是目前可以得到的具有完整功能的稳定的可结合抗原的最小单位。
Single-domain antibody-based noninvasive in vivo imaging of alpha-synuclein or tau pathology. Sci Adv. 2023;9:eadf3775. Article CAS PubMed PubMed Central Google Scholar Fatima A, Wang H, Kang K, Xia L, Wang Y, Ye W, et al. Development of VHH antibodies against dengue virus type 2...